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@ARTICLE{Nano:176970,
      author       = {J. Nano and B. Schöttker$^*$ and J.-S. Lin and C. Huth and
                      M. Ghanbari and P. M. Garcia and H. Maalmi and S. Karrasch
                      and W. Koenig and D. Rothenbacher$^*$ and M. Roden and C.
                      Meisinger and A. Peters and H. Brenner$^*$ and C. Herder and
                      B. Thorand},
      title        = {{N}ovel biomarkers of inflammation, kidney function and
                      chronic kidney disease in the general population.},
      journal      = {Nephrology, dialysis, transplantation},
      volume       = {37},
      number       = {10},
      issn         = {1460-2385},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2021-02203},
      pages        = {1916-1926},
      year         = {2022},
      note         = {2022 Sep 22;37(10):1916-1926},
      abstract     = {Inflammatory processes have been implicated in the
                      development of chronic kidney disease (CKD). We investigated
                      the association of a large panel of inflammatory biomarkers
                      reflecting aspects of immunity with kidney function and CKD
                      incidence.We used data from two independent population-based
                      studies, KORA F4 (discovery, n = 1,110, mean age 70.3
                      years, $48.7\%$ male) and ESTHER (replication, n = 1,672,
                      mean age 61.9 years, $43.6\%$ male). Serum levels of
                      biomarkers were measured using proximity extension assay
                      technology. The association of biomarkers with estimated
                      glomerular filtration rate (eGFR) at baseline and with
                      incident CKD was investigated using linear and logistic
                      regression models adjusted for cardiorenal risk factors.
                      Independent results from prospective analyses of both
                      studies were pooled. The significance level was corrected
                      for multiple testing by false-discovery rate (PFDR
                      < 0.05.).In the KORA F4 discovery study, 52 out of 71
                      inflammatory biomarkers were inversely associated with eGFR
                      estimated based on serum creatinine. Top biomarkers included
                      CD40, TNFRSF9 and IL10RB. Forty-two of these 52 biomarkers
                      were replicated in the ESTHER study. Nine of the 42
                      biomarkers were associated with incident CKD independently
                      of cardiorenal risk factors in the meta-analysis of the KORA
                      (n = 142, mean follow-up of 6.5 years) and ESTHER
                      (n = 103, mean follow-up of 8 years) studies. Pathway
                      analysis revealed the involvement of inflammatory and
                      immunomodulatory processes reflecting cross-communication of
                      innate and adaptive immune cells.Novel and known biomarkers
                      of inflammation were reproducibly associated with kidney
                      function. Future studies should investigate their clinical
                      utility and underlying molecular mechanisms in independent
                      cohorts.},
      keywords     = {chronic kidney disease (Other) / glomerular filtration rate
                      (Other) / inflammation (Other) / population cohort (Other) /
                      proteomics (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34612501},
      doi          = {10.1093/ndt/gfab294},
      url          = {https://inrepo02.dkfz.de/record/176970},
}