000176974 001__ 176974
000176974 005__ 20240229133727.0
000176974 0247_ $$2doi$$a10.1200/JCO.21.00784
000176974 0247_ $$2pmid$$apmid:34618539
000176974 0247_ $$2ISSN$$a0732-183X
000176974 0247_ $$2ISSN$$a1527-7755
000176974 0247_ $$2altmetric$$aaltmetric:114688668
000176974 037__ $$aDKFZ-2021-02207
000176974 041__ $$aEnglish
000176974 082__ $$a610
000176974 1001_ $$00000-0002-8745-4405$$aMaas, Sybren L N$$b0$$eFirst author
000176974 245__ $$aIntegrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated.
000176974 260__ $$aAlexandria, Va.$$bAmerican Society of Clinical Oncology$$c2021
000176974 3367_ $$2DRIVER$$aarticle
000176974 3367_ $$2DataCite$$aOutput Types/Journal article
000176974 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1642429767_11680
000176974 3367_ $$2BibTeX$$aARTICLE
000176974 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000176974 3367_ $$00$$2EndNote$$aJournal Article
000176974 500__ $$a#EA:B300#LA:B300# / 2021 Dec 1;39(34):3839-3852
000176974 520__ $$aMeningiomas are the most frequent primary intracranial tumors. Patient outcome varies widely from benign to highly aggressive, ultimately fatal courses. Reliable identification of risk of progression for individual patients is of pivotal importance. However, only biomarkers for highly aggressive tumors are established (CDKN2A/B and TERT), whereas no molecularly based stratification exists for the broad spectrum of patients with low- and intermediate-risk meningioma.DNA methylation data and copy-number information were generated for 3,031 meningiomas (2,868 patients), and mutation data for 858 samples. DNA methylation subgroups, copy-number variations (CNVs), mutations, and WHO grading were analyzed. Prediction power for outcome was assessed in a retrospective cohort of 514 patients, validated on a retrospective cohort of 184, and on a prospective cohort of 287 multicenter cases.Both CNV- and methylation family-based subgrouping independently resulted in increased prediction accuracy of risk of recurrence compared with the WHO classification (c-indexes WHO 2016, CNV, and methylation family 0.699, 0.706, and 0.721, respectively). Merging all risk stratification approaches into an integrated molecular-morphologic score resulted in further substantial increase in accuracy (c-index 0.744). This integrated score consistently provided superior accuracy in all three cohorts, significantly outperforming WHO grading (c-index difference P = .005). Besides the overall stratification advantage, the integrated score separates more precisely for risk of progression at the diagnostically challenging interface of WHO grade 1 and grade 2 tumors (hazard ratio 4.34 [2.48-7.57] and 3.34 [1.28-8.72] retrospective and prospective validation cohorts, respectively).Merging these layers of histologic and molecular data into an integrated, three-tiered score significantly improves the precision in meningioma stratification. Implementation into diagnostic routine informs clinical decision making for patients with meningioma on the basis of robust outcome prediction.
000176974 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
000176974 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000176974 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b1$$udkfz
000176974 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, Thomas$$b2$$udkfz
000176974 7001_ $$0P:(DE-He78)8aad075b17d93a5636a34942bdbd7ee6$$aSievers, Philipp$$b3$$udkfz
000176974 7001_ $$aBerghoff, Anna S$$b4
000176974 7001_ $$0P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aSchrimpf, Daniel$$b5$$udkfz
000176974 7001_ $$0P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aSill, Martin$$b6$$udkfz
000176974 7001_ $$aEuskirchen, Philipp$$b7
000176974 7001_ $$0P:(DE-He78)a4d58b3605bb0818ae8e3092b8c35182$$aBlume, Christina$$b8$$udkfz
000176974 7001_ $$0P:(DE-He78)79506056c05e539af84edf040f0a93ad$$aPatel Jamilkhan, Areeba$$b9$$udkfz
000176974 7001_ $$0P:(DE-He78)aa809643fc2092db09b893d4d358a0a6$$aDogan, Helin$$b10$$udkfz
000176974 7001_ $$0P:(DE-He78)d5149ffd74f42a2fa87a086d66645aaa$$aReuss, David$$b11$$udkfz
000176974 7001_ $$aDohmen, Hildegard$$b12
000176974 7001_ $$aStein, Marco$$b13
000176974 7001_ $$0P:(DE-He78)856d5c1d0205a79190ed88218ffaf9b2$$aReinhardt, Annekathrin$$b14$$udkfz
000176974 7001_ $$0P:(DE-He78)c77fccff3e6c42b017b2e8a09813590c$$aSuwala, Abigail K$$b15$$udkfz
000176974 7001_ $$0P:(DE-He78)32977c5abc127b0373ece54294a41f63$$aWefers, Annika$$b16$$udkfz
000176974 7001_ $$00000-0002-2563-2691$$aBaumgarten, Peter$$b17
000176974 7001_ $$00000-0002-1321-6930$$aRicklefs, Franz$$b18
000176974 7001_ $$00000-0001-7616-6320$$aRushing, Elisabeth J$$b19
000176974 7001_ $$0P:(DE-He78)7999346780553d7fab7ba69d5afdfa71$$aBewerunge-Hudler, Melanie$$b20$$udkfz
000176974 7001_ $$00000-0001-7790-3425$$aKetter, Ralf$$b21
000176974 7001_ $$00000-0002-9168-6209$$aSchittenhelm, Jens$$b22
000176974 7001_ $$aJaunmuktane, Zane$$b23
000176974 7001_ $$00000-0002-2963-2891$$aLeu, Severina$$b24
000176974 7001_ $$00000-0002-2414-4901$$aGreenway, Fay E A$$b25
000176974 7001_ $$aBridges, Leslie R$$b26
000176974 7001_ $$00000-0003-2037-7334$$aJones, Timothy$$b27
000176974 7001_ $$aGrady, Conor$$b28
000176974 7001_ $$00000-0002-2839-9573$$aSerrano, Jonathan$$b29
000176974 7001_ $$aGolfinos, John$$b30
000176974 7001_ $$00000-0003-1603-2958$$aSen, Chandra$$b31
000176974 7001_ $$aMawrin, Christian$$b32
000176974 7001_ $$aJungk, Christine$$b33
000176974 7001_ $$aHänggi, Daniel$$b34
000176974 7001_ $$aWestphal, Manfred$$b35
000176974 7001_ $$00000-0002-1381-2353$$aLamszus, Katrin$$b36
000176974 7001_ $$aEtminan, Nima$$b37
000176974 7001_ $$aJungwirth, Gerhard$$b38
000176974 7001_ $$aHerold-Mende, Christel$$b39
000176974 7001_ $$aUnterberg, Andreas$$b40
000176974 7001_ $$0P:(DE-He78)b15b56a6ed37417d476470c60c0140ff$$aHarter, Patrick$$b41
000176974 7001_ $$aWirsching, Hans-Georg$$b42
000176974 7001_ $$aNeidert, Marian C$$b43
000176974 7001_ $$aRatliff, Miriam$$b44
000176974 7001_ $$aPlatten, Michael$$b45
000176974 7001_ $$00000-0003-0752-0917$$aSnuderl, Matija$$b46
000176974 7001_ $$00000-0001-5119-7550$$aAldape, Kenneth D$$b47
000176974 7001_ $$00000-0002-9821-0342$$aBrandner, Sebastian$$b48
000176974 7001_ $$00000-0002-9884-1240$$aHench, Jürgen$$b49
000176974 7001_ $$aFrank, Stephan$$b50
000176974 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b51$$udkfz
000176974 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b52$$udkfz
000176974 7001_ $$0P:(DE-HGF)0$$aReifenberger, Guido$$b53
000176974 7001_ $$aAcker, Till$$b54
000176974 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b55$$udkfz
000176974 7001_ $$00000-0002-1748-174X$$aWeller, Michael$$b56
000176974 7001_ $$00000-0003-3541-2315$$aPreusser, Matthias$$b57
000176974 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b58$$udkfz
000176974 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b59$$udkfz
000176974 7001_ $$aMeningiomas, German Consortium on Aggressive$$b60$$eCollaboration Author
000176974 773__ $$0PERI:(DE-600)2005181-5$$a10.1200/JCO.21.00784$$gp. JCO.21.00784$$n34$$p3839-3852$$tJournal of clinical oncology$$v39$$x1527-7755$$y2021
000176974 909CO $$ooai:inrepo02.dkfz.de:176974$$pVDB
000176974 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-8745-4405$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8aad075b17d93a5636a34942bdbd7ee6$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a4d58b3605bb0818ae8e3092b8c35182$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)79506056c05e539af84edf040f0a93ad$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)aa809643fc2092db09b893d4d358a0a6$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d5149ffd74f42a2fa87a086d66645aaa$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)856d5c1d0205a79190ed88218ffaf9b2$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c77fccff3e6c42b017b2e8a09813590c$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)32977c5abc127b0373ece54294a41f63$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7999346780553d7fab7ba69d5afdfa71$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b15b56a6ed37417d476470c60c0140ff$$aDeutsches Krebsforschungszentrum$$b41$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aDeutsches Krebsforschungszentrum$$b51$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)551bb92841f634070997aa168d818492$$aDeutsches Krebsforschungszentrum$$b52$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b53$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aDeutsches Krebsforschungszentrum$$b55$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$aDeutsches Krebsforschungszentrum$$b58$$kDKFZ
000176974 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aDeutsches Krebsforschungszentrum$$b59$$kDKFZ
000176974 9131_ $$0G:(DE-HGF)POF4-312$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunktionelle und strukturelle Genomforschung$$x0
000176974 9141_ $$y2021
000176974 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2021-01-28$$wger
000176974 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ CLIN ONCOL : 2019$$d2021-01-28
000176974 915__ $$0StatID:(DE-HGF)9930$$2StatID$$aIF >= 30$$bJ CLIN ONCOL : 2019$$d2021-01-28
000176974 9201_ $$0I:(DE-He78)B300-20160331$$kB300$$lKKE Neuropathologie$$x0
000176974 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000176974 9201_ $$0I:(DE-He78)C060-20160331$$kC060$$lC060 Biostatistik$$x2
000176974 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lB062 Pädiatrische Neuroonkologie$$x3
000176974 9201_ $$0I:(DE-He78)W110-20160331$$kW110$$lW110 Microarray Unit$$x4
000176974 9201_ $$0I:(DE-He78)FM01-20160331$$kFM01$$lDKTK FM zentral$$x5
000176974 9201_ $$0I:(DE-He78)B360-20160331$$kB360$$lPediatric Glioma$$x6
000176974 9201_ $$0I:(DE-He78)ED01-20160331$$kED01$$lDKTK ED ES zentral$$x7
000176974 9201_ $$0I:(DE-He78)B320-20160331$$kB320$$lKKE Neuroonkologie$$x8
000176974 980__ $$ajournal
000176974 980__ $$aVDB
000176974 980__ $$aI:(DE-He78)B300-20160331
000176974 980__ $$aI:(DE-He78)HD01-20160331
000176974 980__ $$aI:(DE-He78)C060-20160331
000176974 980__ $$aI:(DE-He78)B062-20160331
000176974 980__ $$aI:(DE-He78)W110-20160331
000176974 980__ $$aI:(DE-He78)FM01-20160331
000176974 980__ $$aI:(DE-He78)B360-20160331
000176974 980__ $$aI:(DE-He78)ED01-20160331
000176974 980__ $$aI:(DE-He78)B320-20160331
000176974 980__ $$aUNRESTRICTED