000176978 001__ 176978
000176978 005__ 20240229133727.0
000176978 0247_ $$2doi$$a10.1038/s42003-021-02647-4
000176978 0247_ $$2pmid$$apmid:34615983
000176978 0247_ $$2pmc$$apmc:PMC8494736
000176978 0247_ $$2altmetric$$aaltmetric:114615144
000176978 037__ $$aDKFZ-2021-02211
000176978 041__ $$aEnglish
000176978 082__ $$a570
000176978 1001_ $$00000-0003-1424-6602$$aDaub, Josephine T$$b0
000176978 245__ $$aA systematic analysis of genetic interactions and their underlying biology in childhood cancer.
000176978 260__ $$aLondon$$bSpringer Nature$$c2021
000176978 3367_ $$2DRIVER$$aarticle
000176978 3367_ $$2DataCite$$aOutput Types/Journal article
000176978 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1634112303_29579
000176978 3367_ $$2BibTeX$$aARTICLE
000176978 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000176978 3367_ $$00$$2EndNote$$aJournal Article
000176978 520__ $$aChildhood cancer is a major cause of child death in developed countries. Genetic interactions between mutated genes play an important role in cancer development. They can be detected by searching for pairs of mutated genes that co-occur more (or less) often than expected. Co-occurrence suggests a cooperative role in cancer development, while mutual exclusivity points to synthetic lethality, a phenomenon of interest in cancer treatment research. Little is known about genetic interactions in childhood cancer. We apply a statistical pipeline to detect genetic interactions in a combined dataset comprising over 2,500 tumors from 23 cancer types. The resulting genetic interaction map of childhood cancers comprises 15 co-occurring and 27 mutually exclusive candidates. The biological explanation of most candidates points to either tumor subtype, pathway epistasis or cooperation while synthetic lethality plays a much smaller role. Thus, other explanations beyond synthetic lethality should be considered when interpreting genetic interaction test results.
000176978 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
000176978 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000176978 7001_ $$aAmini, Saman$$b1
000176978 7001_ $$aKersjes, Denise J E$$b2
000176978 7001_ $$00000-0002-6233-2145$$aMa, Xiaotu$$b3
000176978 7001_ $$0P:(DE-He78)bff9e3e3d86865d2b0836bb8f3ce98f3$$aJäger, Natalie$$b4$$udkfz
000176978 7001_ $$00000-0003-3350-9682$$aZhang, Jinghui$$b5
000176978 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b6$$udkfz
000176978 7001_ $$00000-0002-8090-5146$$aHolstege, Frank C P$$b7
000176978 7001_ $$00000-0003-2237-7354$$aKemmeren, Patrick$$b8
000176978 773__ $$0PERI:(DE-600)2919698-X$$a10.1038/s42003-021-02647-4$$gVol. 4, no. 1, p. 1139$$n1$$p1139$$tCommunications biology$$v4$$x2399-3642$$y2021
000176978 909CO $$ooai:inrepo02.dkfz.de:176978$$pVDB
000176978 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)bff9e3e3d86865d2b0836bb8f3ce98f3$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000176978 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000176978 9131_ $$0G:(DE-HGF)POF4-312$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunktionelle und strukturelle Genomforschung$$x0
000176978 9141_ $$y2021
000176978 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCOMMUN BIOL : 2019$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-06-15
000176978 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-06-15
000176978 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-06-15
000176978 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lB062 Pädiatrische Neuroonkologie$$x0
000176978 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000176978 980__ $$ajournal
000176978 980__ $$aVDB
000176978 980__ $$aI:(DE-He78)B062-20160331
000176978 980__ $$aI:(DE-He78)HD01-20160331
000176978 980__ $$aUNRESTRICTED