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@ARTICLE{Daub:176978,
      author       = {J. T. Daub and S. Amini and D. J. E. Kersjes and X. Ma and
                      N. Jäger$^*$ and J. Zhang and S. M. Pfister$^*$ and F. C.
                      P. Holstege and P. Kemmeren},
      title        = {{A} systematic analysis of genetic interactions and their
                      underlying biology in childhood cancer.},
      journal      = {Communications biology},
      volume       = {4},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2021-02211},
      pages        = {1139},
      year         = {2021},
      abstract     = {Childhood cancer is a major cause of child death in
                      developed countries. Genetic interactions between mutated
                      genes play an important role in cancer development. They can
                      be detected by searching for pairs of mutated genes that
                      co-occur more (or less) often than expected. Co-occurrence
                      suggests a cooperative role in cancer development, while
                      mutual exclusivity points to synthetic lethality, a
                      phenomenon of interest in cancer treatment research. Little
                      is known about genetic interactions in childhood cancer. We
                      apply a statistical pipeline to detect genetic interactions
                      in a combined dataset comprising over 2,500 tumors from 23
                      cancer types. The resulting genetic interaction map of
                      childhood cancers comprises 15 co-occurring and 27 mutually
                      exclusive candidates. The biological explanation of most
                      candidates points to either tumor subtype, pathway epistasis
                      or cooperation while synthetic lethality plays a much
                      smaller role. Thus, other explanations beyond synthetic
                      lethality should be considered when interpreting genetic
                      interaction test results.},
      cin          = {B062 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34615983},
      pmc          = {pmc:PMC8494736},
      doi          = {10.1038/s42003-021-02647-4},
      url          = {https://inrepo02.dkfz.de/record/176978},
}