000176989 001__ 176989
000176989 005__ 20240229133727.0
000176989 0247_ $$2doi$$a10.20517/jtgg.2021.08
000176989 0247_ $$2pmid$$apmid:34622145
000176989 0247_ $$2pmc$$apmc:PMC8494431
000176989 0247_ $$2altmetric$$aaltmetric:114732349
000176989 037__ $$aDKFZ-2021-02222
000176989 041__ $$aEnglish
000176989 1001_ $$aMoore, Amy$$b0
000176989 245__ $$aGenome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
000176989 260__ $$aErscheinungsort nicht ermittelbar$$c2021
000176989 3367_ $$2DRIVER$$aarticle
000176989 3367_ $$2DataCite$$aOutput Types/Journal article
000176989 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1693388903_15639
000176989 3367_ $$2BibTeX$$aARTICLE
000176989 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000176989 3367_ $$00$$2EndNote$$aJournal Article
000176989 500__ $$aJournal of Translational Genetics and Genomics (jtgg) = 2578-5281 (import from CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de)
000176989 520__ $$aRecessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. We sought to examine genome-wide homozygosity and NHL risk.We used data from eight genome-wide association studies of four common NHL subtypes: 3061 chronic lymphocytic leukemia (CLL), 3814 diffuse large B-cell lymphoma (DLBCL), 2784 follicular lymphoma (FL), and 808 marginal zone lymphoma (MZL) cases, as well as 9374 controls. We examined the effect of homozygous variation on risk by: (1) estimating the fraction of the autosome containing runs of homozygosity (FROH); (2) calculating an inbreeding coefficient derived from the correlation among uniting gametes (F3); and (3) examining specific autosomal regions containing ROH. For each, we calculated beta coefficients and standard errors using logistic regression and combined estimates across studies using random-effects meta-analysis.We discovered positive associations between FROH and CLL (β = 21.1, SE = 4.41, P = 1.6 × 10-6) and FL (β = 11.4, SE = 5.82, P = 0.02) but not DLBCL (P = 1.0) or MZL (P = 0.91). For F3, we observed an association with CLL (β = 27.5, SE = 6.51, P = 2.4 × 10-5). We did not find evidence of associations with specific ROH, suggesting that the associations observed with FROH and F3 for CLL and FL risk were not driven by a single region of homozygosity.Our findings support the role of recessive genetic variation in the etiology of CLL and FL; additional research is needed to identify the specific loci associated with NHL risk.
000176989 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000176989 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000176989 650_7 $$2Other$$aNon-Hodgkin lymphoma
000176989 650_7 $$2Other$$achronic lymphocytic leukemia
000176989 650_7 $$2Other$$adiffuse large B-cell lymphoma
000176989 650_7 $$2Other$$afollicular lymphoma
000176989 650_7 $$2Other$$ahomozygosity
000176989 650_7 $$2Other$$amarginal zone lymphoma
000176989 7001_ $$aMachiela, Mitchell J$$b1
000176989 7001_ $$aMachado, Moara$$b2
000176989 7001_ $$aWang, Sophia S$$b3
000176989 7001_ $$aKane, Eleanor$$b4
000176989 7001_ $$aSlager, Susan L$$b5
000176989 7001_ $$aZhou, Weiyin$$b6
000176989 7001_ $$aCarrington, Mary$$b7
000176989 7001_ $$aLan, Qing$$b8
000176989 7001_ $$aMilne, Roger L$$b9
000176989 7001_ $$aBirmann, Brenda M$$b10
000176989 7001_ $$aAdami, Hans-Olov$$b11
000176989 7001_ $$aAlbanes, Demetrius$$b12
000176989 7001_ $$aArslan, Alan A$$b13
000176989 7001_ $$0P:(DE-He78)1573258b58c33f1922ca9719d0c8c4ab$$aBecker, Nikolaus$$b14$$udkfz
000176989 7001_ $$aBenavente, Yolanda$$b15
000176989 7001_ $$aBisanzi, Simonetta$$b16
000176989 7001_ $$aBoffetta, Paolo$$b17
000176989 7001_ $$aBracci, Paige M$$b18
000176989 7001_ $$aBrennan, Paul$$b19
000176989 7001_ $$aBrooks-Wilson, Angela R$$b20
000176989 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b21$$udkfz
000176989 7001_ $$aCaporaso, Neil$$b22
000176989 7001_ $$aClavel, Jacqueline$$b23
000176989 7001_ $$aCocco, Pierluigi$$b24
000176989 7001_ $$aConde, Lucia$$b25
000176989 7001_ $$aCox, David G$$b26
000176989 7001_ $$aCozen, Wendy$$b27
000176989 7001_ $$aCurtin, Karen$$b28
000176989 7001_ $$aDe Vivo, Immaculata$$b29
000176989 7001_ $$ade Sanjose, Silvia$$b30
000176989 7001_ $$aForetova, Lenka$$b31
000176989 7001_ $$aGapstur, Susan M$$b32
000176989 7001_ $$aGhesquières, Hervè$$b33
000176989 7001_ $$aGiles, Graham G$$b34
000176989 7001_ $$aGlenn, Martha$$b35
000176989 7001_ $$aGlimelius, Bengt$$b36
000176989 7001_ $$aGao, Chi$$b37
000176989 7001_ $$aHabermann, Thomas M$$b38
000176989 7001_ $$aHjalgrim, Henrik$$b39
000176989 7001_ $$aJackson, Rebecca D$$b40
000176989 7001_ $$aLiebow, Mark$$b41
000176989 7001_ $$aLink, Brian K$$b42
000176989 7001_ $$aMaynadie, Marc$$b43
000176989 7001_ $$aMcKay, James$$b44
000176989 7001_ $$aMelbye, Mads$$b45
000176989 7001_ $$aMiligi, Lucia$$b46
000176989 7001_ $$aMolina, Thierry J$$b47
000176989 7001_ $$aMonnereau, Alain$$b48
000176989 7001_ $$aNieters, Alexandra$$b49
000176989 7001_ $$aNorth, Kari E$$b50
000176989 7001_ $$aOffit, Kenneth$$b51
000176989 7001_ $$aPatel, Alpa V$$b52
000176989 7001_ $$aPiro, Sara$$b53
000176989 7001_ $$aRavichandran, Vignesh$$b54
000176989 7001_ $$aRiboli, Elio$$b55
000176989 7001_ $$aSalles, Gilles$$b56
000176989 7001_ $$aSeverson, Richard K$$b57
000176989 7001_ $$aSkibola, Christine F$$b58
000176989 7001_ $$aSmedby, Karin E$$b59
000176989 7001_ $$aSouthey, Melissa C$$b60
000176989 7001_ $$aSpinelli, John J$$b61
000176989 7001_ $$aStaines, Anthony$$b62
000176989 7001_ $$aStewart, Carolyn$$b63
000176989 7001_ $$aTeras, Lauren R$$b64
000176989 7001_ $$aTinker, Lesley F$$b65
000176989 7001_ $$aTravis, Ruth C$$b66
000176989 7001_ $$aVajdic, Claire M$$b67
000176989 7001_ $$aVermeulen, Roel C H$$b68
000176989 7001_ $$aVijai, Joseph$$b69
000176989 7001_ $$aWeiderpass, Elisabete$$b70
000176989 7001_ $$aWeinstein, Stephanie$$b71
000176989 7001_ $$aDoo, Nicole Wong$$b72
000176989 7001_ $$aZhang, Yawei$$b73
000176989 7001_ $$aZheng, Tongzhang$$b74
000176989 7001_ $$aChanock, Stephen J$$b75
000176989 7001_ $$aRothman, Nathaniel$$b76
000176989 7001_ $$aCerhan, James R$$b77
000176989 7001_ $$aDean, Michael$$b78
000176989 7001_ $$aCamp, Nicola J$$b79
000176989 7001_ $$aYeager, Meredith$$b80
000176989 7001_ $$aBerndt, Sonja I$$b81
000176989 773__ $$0PERI:(DE-600)3104319-7$$a10.20517/jtgg.2021.08$$gVol. 5$$p200-217$$tJournal of Translational Genetics and Genomics$$v5$$x2578-5281$$y2021
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000176989 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0
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