TY  - JOUR
AU  - Moore, Amy
AU  - Machiela, Mitchell J
AU  - Machado, Moara
AU  - Wang, Sophia S
AU  - Kane, Eleanor
AU  - Slager, Susan L
AU  - Zhou, Weiyin
AU  - Carrington, Mary
AU  - Lan, Qing
AU  - Milne, Roger L
AU  - Birmann, Brenda M
AU  - Adami, Hans-Olov
AU  - Albanes, Demetrius
AU  - Arslan, Alan A
AU  - Becker, Nikolaus
AU  - Benavente, Yolanda
AU  - Bisanzi, Simonetta
AU  - Boffetta, Paolo
AU  - Bracci, Paige M
AU  - Brennan, Paul
AU  - Brooks-Wilson, Angela R
AU  - Canzian, Federico
AU  - Caporaso, Neil
AU  - Clavel, Jacqueline
AU  - Cocco, Pierluigi
AU  - Conde, Lucia
AU  - Cox, David G
AU  - Cozen, Wendy
AU  - Curtin, Karen
AU  - De Vivo, Immaculata
AU  - de Sanjose, Silvia
AU  - Foretova, Lenka
AU  - Gapstur, Susan M
AU  - Ghesquières, Hervè
AU  - Giles, Graham G
AU  - Glenn, Martha
AU  - Glimelius, Bengt
AU  - Gao, Chi
AU  - Habermann, Thomas M
AU  - Hjalgrim, Henrik
AU  - Jackson, Rebecca D
AU  - Liebow, Mark
AU  - Link, Brian K
AU  - Maynadie, Marc
AU  - McKay, James
AU  - Melbye, Mads
AU  - Miligi, Lucia
AU  - Molina, Thierry J
AU  - Monnereau, Alain
AU  - Nieters, Alexandra
AU  - North, Kari E
AU  - Offit, Kenneth
AU  - Patel, Alpa V
AU  - Piro, Sara
AU  - Ravichandran, Vignesh
AU  - Riboli, Elio
AU  - Salles, Gilles
AU  - Severson, Richard K
AU  - Skibola, Christine F
AU  - Smedby, Karin E
AU  - Southey, Melissa C
AU  - Spinelli, John J
AU  - Staines, Anthony
AU  - Stewart, Carolyn
AU  - Teras, Lauren R
AU  - Tinker, Lesley F
AU  - Travis, Ruth C
AU  - Vajdic, Claire M
AU  - Vermeulen, Roel C H
AU  - Vijai, Joseph
AU  - Weiderpass, Elisabete
AU  - Weinstein, Stephanie
AU  - Doo, Nicole Wong
AU  - Zhang, Yawei
AU  - Zheng, Tongzhang
AU  - Chanock, Stephen J
AU  - Rothman, Nathaniel
AU  - Cerhan, James R
AU  - Dean, Michael
AU  - Camp, Nicola J
AU  - Yeager, Meredith
AU  - Berndt, Sonja I
TI  - Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
JO  - Journal of Translational Genetics and Genomics
VL  - 5
SN  - 2578-5281
CY  - Erscheinungsort nicht ermittelbar
M1  - DKFZ-2021-02222
SP  - 200-217
PY  - 2021
N1  - Journal of Translational Genetics and Genomics (jtgg) = 2578-5281 (import from CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de)
AB  - Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. We sought to examine genome-wide homozygosity and NHL risk.We used data from eight genome-wide association studies of four common NHL subtypes: 3061 chronic lymphocytic leukemia (CLL), 3814 diffuse large B-cell lymphoma (DLBCL), 2784 follicular lymphoma (FL), and 808 marginal zone lymphoma (MZL) cases, as well as 9374 controls. We examined the effect of homozygous variation on risk by: (1) estimating the fraction of the autosome containing runs of homozygosity (FROH); (2) calculating an inbreeding coefficient derived from the correlation among uniting gametes (F3); and (3) examining specific autosomal regions containing ROH. For each, we calculated beta coefficients and standard errors using logistic regression and combined estimates across studies using random-effects meta-analysis.We discovered positive associations between FROH and CLL (β = 21.1, SE = 4.41, P = 1.6 × 10-6) and FL (β = 11.4, SE = 5.82, P = 0.02) but not DLBCL (P = 1.0) or MZL (P = 0.91). For F3, we observed an association with CLL (β = 27.5, SE = 6.51, P = 2.4 × 10-5). We did not find evidence of associations with specific ROH, suggesting that the associations observed with FROH and F3 for CLL and FL risk were not driven by a single region of homozygosity.Our findings support the role of recessive genetic variation in the etiology of CLL and FL; additional research is needed to identify the specific loci associated with NHL risk.
KW  - Non-Hodgkin lymphoma (Other)
KW  - chronic lymphocytic leukemia (Other)
KW  - diffuse large B-cell lymphoma (Other)
KW  - follicular lymphoma (Other)
KW  - homozygosity (Other)
KW  - marginal zone lymphoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34622145
C2  - pmc:PMC8494431
DO  - DOI:10.20517/jtgg.2021.08
UR  - https://inrepo02.dkfz.de/record/176989
ER  -