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@ARTICLE{Kannenkeril:176991,
      author       = {D. Kannenkeril and S. Jung and J. Harazny and K. Striepe
                      and C. Ott and A. Dahlmann and C. Kopp and M. Schiffer and
                      P. Linz and A. M. Nagel$^*$ and M. Uder and R. E. Schmieder},
      title        = {{T}issue sodium content correlates with hypertrophic
                      vascular remodeling in type 2 diabetes.},
      journal      = {Journal of diabetes and its complications},
      volume       = {35},
      number       = {12},
      issn         = {1056-8727},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2021-02224},
      pages        = {108055},
      year         = {2021},
      note         = {2021 Dec;35(12):108055},
      abstract     = {Prospective studies describe a linkage between increased
                      sodium intake and higher incidence of cardiovascular organ
                      damage and end points. We analyzed whether tissue sodium
                      content in the skin and muscles correlate with vascular
                      hypertrophic remodeling, a risk factor for cardiovascular
                      disease.In patients with type 2 diabetes we assessed tissue
                      sodium content and vascular structural parameters of the
                      retinal arterioles. The structural parameters of retinal
                      arterioles assessed by Scanning Laser Doppler Flowmetry were
                      vessel (VD) and lumen diameter (LD), wall thickness (WT),
                      wall-to-lumen ratio (WLR) and wall cross sectional area
                      (WCSA). Tissue sodium content was measured with a 3.0 T
                      clinical 23Sodium-Magnetic Resonance Imaging (23Na-MRI)
                      system.In patients with type 2 diabetes (N = 52) we
                      observed a significant correlation between muscle sodium
                      content and VD (p = 0.005), WT (p = 0.003), WCSA
                      (p = 0.002) and WLR (p = 0.013). With respect to skin
                      sodium content a significant correlation has been found with
                      VD (p = 0.042), WT (p = 0.023) and WCSA (p = 0.019).
                      Further analysis demonstrated that tissue sodium content of
                      skin and muscle is a significant determinant of hypertrophic
                      vascular remodeling independent of age, gender, diuretic use
                      and 24-hour ambulatory BP.With the 23Na-MRI technology we
                      could demonstrate that high tissue sodium content is
                      independently linked to hypertrophic vascular remodeling in
                      type 2 diabetes.Trial registration number: NCT02383238 Date
                      of registration: March 9, 2015.},
      keywords     = {(23)Na-MRI (Other) / Tissue sodium (Other) / Type 2
                      diabetes mellitus (Other) / Vascular remodeling (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34620556},
      doi          = {10.1016/j.jdiacomp.2021.108055},
      url          = {https://inrepo02.dkfz.de/record/176991},
}