000177003 001__ 177003
000177003 005__ 20240229133728.0
000177003 0247_ $$2doi$$a10.1093/ve/veab058
000177003 0247_ $$2pmid$$apmid:34532061
000177003 0247_ $$2pmc$$apmc:PMC8438875
000177003 037__ $$aDKFZ-2021-02236
000177003 041__ $$aEnglish
000177003 082__ $$a610
000177003 1001_ $$00000-0001-7331-7357$$aHodel, F.$$b0
000177003 245__ $$aHuman genomics of the humoral immune response against polyomaviruses.
000177003 260__ $$aOxford$$bOxford Univ. Press$$c2021
000177003 3367_ $$2DRIVER$$aarticle
000177003 3367_ $$2DataCite$$aOutput Types/Journal article
000177003 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1635318133_28977
000177003 3367_ $$2BibTeX$$aARTICLE
000177003 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000177003 3367_ $$00$$2EndNote$$aJournal Article
000177003 520__ $$aHuman polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta-analyses of qualitative and quantitative immunoglobulin G responses against BK polyomavirus (BKPyV), JC polyomavirus (JCPyV), Merkel cellpolyomavirus (MCPyV), WU polyomavirus (WUPyV), and human polyomavirus 6 (HPyV6) in 15,660 individuals of European ancestry from three independent studies. We observed significant associations for all tested viruses: JCPyV, HPyV6, and MCPyV associated with human leukocyte antigen class II variation, BKPyV and JCPyV with variants in FUT2, responsible for secretor status, MCPyV with variants in STING1, involved in interferon induction, and WUPyV with a functional variant in MUC1, previously associated with risk for gastric cancer. These results provide insights into the genetic control of a family of very prevalent human viruses, highlighting genes and pathways that play a modulating role in human humoral immunity.
000177003 536__ $$0G:(DE-HGF)POF4-316$$a316 - Infektionen, Entzündung und Krebs (POF4-316)$$cPOF4-316$$fPOF IV$$x0
000177003 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000177003 650_7 $$2Other$$aGWAS
000177003 650_7 $$2Other$$agenomics
000177003 650_7 $$2Other$$ahuman
000177003 650_7 $$2Other$$ainfection
000177003 650_7 $$2Other$$ameta-analysis
000177003 650_7 $$2Other$$apolyomavirus
000177003 7001_ $$aChong, A. Y.$$b1
000177003 7001_ $$aScepanovic, P.$$b2
000177003 7001_ $$aXu, Z. M.$$b3
000177003 7001_ $$aNaret, O.$$b4
000177003 7001_ $$aThorball, C. W.$$b5
000177003 7001_ $$aRüeger, S.$$b6
000177003 7001_ $$aMarques-Vidal, P.$$b7
000177003 7001_ $$00000-0002-0765-896X$$aVollenweider, P.$$b8
000177003 7001_ $$aBegemann, M.$$b9
000177003 7001_ $$aEhrenreich, H.$$b10
000177003 7001_ $$0P:(DE-He78)b1326dc42cbbc5f92b10fe5f254f0bc2$$aBrenner, N.$$b11$$udkfz
000177003 7001_ $$0P:(DE-He78)540833b33724d8def638cce2f0b4e187$$aBender, N.$$b12$$udkfz
000177003 7001_ $$0P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aWaterboer, T.$$b13$$udkfz
000177003 7001_ $$00000-0002-4502-2209$$aMentzer, A. J.$$b14
000177003 7001_ $$aHill, A. V. S.$$b15
000177003 7001_ $$00000-0003-4548-7548$$aHammer, C.$$b16
000177003 7001_ $$aFellay, J.$$b17
000177003 773__ $$0PERI:(DE-600)2818949-8$$a10.1093/ve/veab058$$gVol. 7, no. 2, p. veab058$$n2$$pveab058$$tVirus evolution$$v7$$x2057-1577$$y2021
000177003 909CO $$ooai:inrepo02.dkfz.de:177003$$pVDB
000177003 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b1326dc42cbbc5f92b10fe5f254f0bc2$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000177003 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)540833b33724d8def638cce2f0b4e187$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000177003 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000177003 9131_ $$0G:(DE-HGF)POF4-316$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vInfektionen, Entzündung und Krebs$$x0
000177003 9141_ $$y2021
000177003 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2020-09-06
000177003 915__ $$0LIC:(DE-HGF)CCBYNCNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial CC BY-NC (No Version)$$bDOAJ$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-09-06
000177003 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-09-06
000177003 9201_ $$0I:(DE-He78)F022-20160331$$kF022$$lInfektionen und Krebs-Epidemiologie$$x0
000177003 9201_ $$0I:(DE-He78)F020-20160331$$kF020$$lInfektionen und Krebs-Epidemiologie$$x1
000177003 980__ $$ajournal
000177003 980__ $$aVDB
000177003 980__ $$aI:(DE-He78)F022-20160331
000177003 980__ $$aI:(DE-He78)F020-20160331
000177003 980__ $$aUNRESTRICTED