000177020 001__ 177020
000177020 005__ 20240419143147.0
000177020 0247_ $$2doi$$a10.1038/s41467-021-26151-9
000177020 0247_ $$2pmid$$apmid:34642315
000177020 0247_ $$2altmetric$$aaltmetric:115117529
000177020 037__ $$aDKFZ-2021-02250
000177020 041__ $$aEnglish
000177020 082__ $$a500
000177020 1001_ $$00000-0002-1458-7936$$aFerreiro-Iglesias, Aida$$b0
000177020 245__ $$aGermline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer.
000177020 260__ $$a[London]$$bNature Publishing Group UK$$c2021
000177020 3367_ $$2DRIVER$$aarticle
000177020 3367_ $$2DataCite$$aOutput Types/Journal article
000177020 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1713529874_15505
000177020 3367_ $$2BibTeX$$aARTICLE
000177020 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000177020 3367_ $$00$$2EndNote$$aJournal Article
000177020 520__ $$aAlthough several oropharyngeal cancer (OPC) susceptibility loci have been identified, most previous studies lacked detailed information on human papillomavirus (HPV) status. We conduct a genome-wide analysis by HPV16 serology status in 4,002 oral cancer cases (OPC and oral cavity cancer (OCC)) and 5,256 controls. We detect four susceptibility loci pointing to a distinct genetic predisposition by HPV status. Our most notable finding in the HLA region, that is now confirmed to be specific of HPV(+)OPC risk, reveal two independent loci with strong protective effects, one refining the previously reported HLA class II haplotype association. Antibody levels against HPV16 viral proteins strongly implicate the protective HLA variants as major determinants of humoral response against L1 capsid protein or E6 oncoprotein suggesting a natural immune response against HPV(+)OPC promoted by HLA variants. This indicates that therapeutic vaccines that target E6 and attenuate viral response after established HPV infections might protect against HPV(+)OPC.
000177020 536__ $$0G:(DE-HGF)POF4-316$$a316 - Infektionen, Entzündung und Krebs (POF4-316)$$cPOF4-316$$fPOF IV$$x0
000177020 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000177020 7001_ $$aMcKay, James D$$b1
000177020 7001_ $$0P:(DE-He78)b1326dc42cbbc5f92b10fe5f254f0bc2$$aBrenner, Nicole$$b2
000177020 7001_ $$00000-0002-1163-432X$$aVirani, Shama$$b3
000177020 7001_ $$00000-0001-6744-6750$$aLesseur, Corina$$b4
000177020 7001_ $$aGaborieau, Valerie$$b5
000177020 7001_ $$aNess, Andy R$$b6
000177020 7001_ $$00000-0002-4486-7496$$aHung, Rayjean J$$b7
000177020 7001_ $$aLiu, Geoffrey$$b8
000177020 7001_ $$aDiergaarde, Brenda$$b9
000177020 7001_ $$aOlshan, Andrew F$$b10
000177020 7001_ $$00000-0001-6203-7771$$aHayes, Neil$$b11
000177020 7001_ $$aWeissler, Mark C$$b12
000177020 7001_ $$0P:(DE-He78)b12aaacaa142dabed85c6d84d00bf0fb$$aSchroeder, Lea$$b13
000177020 7001_ $$0P:(DE-He78)540833b33724d8def638cce2f0b4e187$$aBender, Noemi$$b14
000177020 7001_ $$0P:(DE-He78)d99bad949ba3ae93859eedae5ac266da$$aPawlita, Michael$$b15
000177020 7001_ $$aThomas, Steve$$b16
000177020 7001_ $$aPring, Miranda$$b17
000177020 7001_ $$00000-0003-3756-040X$$aDudding, Tom$$b18
000177020 7001_ $$aKanterewicz, Beatriz$$b19
000177020 7001_ $$aFerris, Robert$$b20
000177020 7001_ $$aThomas, Sera$$b21
000177020 7001_ $$aBrhane, Yonathan$$b22
000177020 7001_ $$aDíez-Obrero, Virginia$$b23
000177020 7001_ $$00000-0002-8248-8884$$aMilojevic, Maja$$b24
000177020 7001_ $$00000-0002-1932-7463$$aSmith-Byrne, Karl$$b25
000177020 7001_ $$00000-0001-8181-1419$$aMariosa, Daniela$$b26
000177020 7001_ $$00000-0002-3116-5081$$aJohansson, Mattias J$$b27
000177020 7001_ $$aHerrero, Rolando$$b28
000177020 7001_ $$aBoccia, Stefania$$b29
000177020 7001_ $$aCadoni, Gabriella$$b30
000177020 7001_ $$00000-0003-2868-4822$$aLacko, Martin$$b31
000177020 7001_ $$aHolcátová, Ivana$$b32
000177020 7001_ $$aAhrens, Wolfgang$$b33
000177020 7001_ $$aLagiou, Pagona$$b34
000177020 7001_ $$aLagiou, Areti$$b35
000177020 7001_ $$00000-0001-9381-1520$$aPolesel, Jerry$$b36
000177020 7001_ $$aSimonato, Lorenzo$$b37
000177020 7001_ $$aMerletti, Franco$$b38
000177020 7001_ $$aHealy, Claire M$$b39
000177020 7001_ $$aHansen, Bo T$$b40
000177020 7001_ $$aNygård, Mari$$b41
000177020 7001_ $$aConway, David I$$b42
000177020 7001_ $$aWright, Sylvia$$b43
000177020 7001_ $$aMacfarlane, Tatiana V$$b44
000177020 7001_ $$00000-0003-4491-6865$$aRobinson, Max$$b45
000177020 7001_ $$aAlemany, Laia$$b46
000177020 7001_ $$aAgudo, Antonio$$b47
000177020 7001_ $$00000-0002-5849-4782$$aZnaor, Ariana$$b48
000177020 7001_ $$aAmos, Christopher I$$b49
000177020 7001_ $$0P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aWaterboer, Tim$$b50$$eLast author$$udkfz
000177020 7001_ $$00000-0002-0518-8714$$aBrennan, Paul$$b51
000177020 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-021-26151-9$$gVol. 12, no. 1, p. 5945$$n1$$p5945$$tNature Communications$$v12$$x2041-1723$$y2021
000177020 909CO $$ooai:inrepo02.dkfz.de:177020$$pVDB
000177020 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b1326dc42cbbc5f92b10fe5f254f0bc2$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000177020 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b12aaacaa142dabed85c6d84d00bf0fb$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000177020 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)540833b33724d8def638cce2f0b4e187$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000177020 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d99bad949ba3ae93859eedae5ac266da$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000177020 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aDeutsches Krebsforschungszentrum$$b50$$kDKFZ
000177020 9131_ $$0G:(DE-HGF)POF4-316$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vInfektionen, Entzündung und Krebs$$x0
000177020 9141_ $$y2021
000177020 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2019$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2021-02-02
000177020 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNAT COMMUN : 2019$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-02-02
000177020 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-02-02
000177020 9201_ $$0I:(DE-He78)F022-20160331$$kF022$$lInfektionen und Krebs-Epidemiologie$$x0
000177020 9201_ $$0I:(DE-He78)F020-20160331$$kF020$$lInfektionen und Krebs-Epidemiologie$$x1
000177020 980__ $$ajournal
000177020 980__ $$aVDB
000177020 980__ $$aI:(DE-He78)F022-20160331
000177020 980__ $$aI:(DE-He78)F020-20160331
000177020 980__ $$aUNRESTRICTED