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@ARTICLE{FerreiroIglesias:177020,
      author       = {A. Ferreiro-Iglesias and J. D. McKay and N. Brenner$^*$ and
                      S. Virani and C. Lesseur and V. Gaborieau and A. R. Ness and
                      R. J. Hung and G. Liu and B. Diergaarde and A. F. Olshan and
                      N. Hayes and M. C. Weissler and L. Schroeder$^*$ and N.
                      Bender$^*$ and M. Pawlita$^*$ and S. Thomas and M. Pring and
                      T. Dudding and B. Kanterewicz and R. Ferris and S. Thomas
                      and Y. Brhane and V. Díez-Obrero and M. Milojevic and K.
                      Smith-Byrne and D. Mariosa and M. J. Johansson and R.
                      Herrero and S. Boccia and G. Cadoni and M. Lacko and I.
                      Holcátová and W. Ahrens and P. Lagiou and A. Lagiou and J.
                      Polesel and L. Simonato and F. Merletti and C. M. Healy and
                      B. T. Hansen and M. Nygård and D. I. Conway and S. Wright
                      and T. V. Macfarlane and M. Robinson and L. Alemany and A.
                      Agudo and A. Znaor and C. I. Amos and T. Waterboer$^*$ and
                      P. Brennan},
      title        = {{G}ermline determinants of humoral immune response to
                      {HPV}-16 protect against oropharyngeal cancer.},
      journal      = {Nature Communications},
      volume       = {12},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2021-02250},
      pages        = {5945},
      year         = {2021},
      abstract     = {Although several oropharyngeal cancer (OPC) susceptibility
                      loci have been identified, most previous studies lacked
                      detailed information on human papillomavirus (HPV) status.
                      We conduct a genome-wide analysis by HPV16 serology status
                      in 4,002 oral cancer cases (OPC and oral cavity cancer
                      (OCC)) and 5,256 controls. We detect four susceptibility
                      loci pointing to a distinct genetic predisposition by HPV
                      status. Our most notable finding in the HLA region, that is
                      now confirmed to be specific of HPV(+)OPC risk, reveal two
                      independent loci with strong protective effects, one
                      refining the previously reported HLA class II haplotype
                      association. Antibody levels against HPV16 viral proteins
                      strongly implicate the protective HLA variants as major
                      determinants of humoral response against L1 capsid protein
                      or E6 oncoprotein suggesting a natural immune response
                      against HPV(+)OPC promoted by HLA variants. This indicates
                      that therapeutic vaccines that target E6 and attenuate viral
                      response after established HPV infections might protect
                      against HPV(+)OPC.},
      cin          = {F022 / F020},
      ddc          = {500},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34642315},
      doi          = {10.1038/s41467-021-26151-9},
      url          = {https://inrepo02.dkfz.de/record/177020},
}