%0 Journal Article
%A Schmid, Simone
%A Solomon, David A
%A Perez, Eilis
%A Thieme, Anne
%A Kleinschmidt-DeMasters, Bette K
%A Giannini, Caterina
%A Reinhardt, Annekathrin
%A Asa, Sylvia L
%A Mete, Ozgur
%A Stichel, Damian
%A Siewert, Christin
%A Dittmayer, Carsten
%A Hasselblatt, Martin
%A Paulus, Werner
%A Nagel, Christoph
%A Harter, Patrick
%A Schittenhelm, Jens
%A Honegger, Jürgen
%A Rushing, Elisabeth
%A Coras, Roland
%A Pfister, Stefan M
%A Buslei, Rolf
%A Koch, Arend
%A Perry, Arie
%A Jones, David T W
%A von Deimling, Andreas
%A Capper, David
%A Lopes, M Beatriz
%T Genetic and epigenetic characterization of posterior pituitary tumors.
%J Acta neuropathologica
%V 142
%N 6
%@ 1432-0533
%C Heidelberg
%I Springer
%M DKFZ-2021-02291
%P 1025-1043
%D 2021
%Z 2021 Dec;142(6):1025-1043
%X Pituicytoma (PITUI), granular cell tumor (GCT), and spindle cell oncocytoma (SCO) are rare tumors of the posterior pituitary. Histologically, they may be challenging to distinguish and have been proposed to represent a histological spectrum of a single entity. We performed targeted next-generation sequencing, DNA methylation profiling, and copy number analysis on 47 tumors (14 PITUI; 12 GCT; 21 SCO) to investigate molecular features and explore possibilities of clinically meaningful tumor subclassification. We detected two main epigenomic subgroups by unsupervised clustering of DNA methylation data, though the overall methylation differences were subtle. The largest group (n = 23) contained most PITUIs and a subset of SCOs and was enriched for pathogenic mutations within genes in the MAPK/PI3K pathways (12/17 [71
%K Brain tumor (Other)
%K Granular cell tumor (Other)
%K Molecular neuropathology (Other)
%K Pituicytoma (Other)
%K Posterior pituitary gland neoplasms (Other)
%K Spindle cell oncocytoma (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34661724
%R 10.1007/s00401-021-02377-1
%U https://inrepo02.dkfz.de/record/177085