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@ARTICLE{Li:177192,
      author       = {Z. Li$^*$ and F. Baccianti$^*$ and S. Delecluse$^*$ and
                      M.-H. Tsai and A. Shumilov$^*$ and X. Cheng$^*$ and S.
                      Ma$^*$ and I. Hoffmann$^*$ and R. Poirey$^*$ and H.-J.
                      Delecluse$^*$},
      title        = {{T}he {E}pstein-{B}arr virus noncoding {RNA} {EBER}2
                      transactivates the {UCHL}1 deubiquitinase to accelerate cell
                      growth.},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {118},
      number       = {43},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {DKFZ-2021-02326},
      pages        = {e2115508118 -},
      year         = {2021},
      note         = {#EA:F100#LA:F100#},
      abstract     = {The Epstein-Barr virus (EBV) transforms resting B cells and
                      is involved in the development of B cell lymphomas. We
                      report here that the viral noncoding RNA EBER2 accelerates B
                      cell growth by potentiating expression of the UCHL1
                      deubiquitinase that itself increased expression of the
                      Aurora kinases and of cyclin B1. Importantly, this effect
                      was also visible in Burkitt's lymphoma cells that express
                      none of the virus's known oncogenes. Mechanistically, EBER2
                      bound the UCHL1 messenger RNA (mRNA), thereby bringing a
                      protein complex that includes PU.1, a UCHL1 transactivator,
                      to the vicinity of its promoter. Although the EBV oncogene
                      LMP1 has been suggested to induce UCHL1, we show here that
                      EBER2 plays a much more important role to reach significant
                      levels of the deubiquitinase in infected cells. However,
                      some viruses that carried a polymorphic LMP1 had an
                      increased ability to achieve full UCHL1 expression. This
                      work identifies a direct cellular target of a viral
                      noncoding RNA that is likely to be central to EBV's
                      oncogenic properties.},
      keywords     = {B cell lymphomas (Other) / Epstein–Barr virus (Other) /
                      UCHL1 (Other) / noncoding RNA EBER2 (Other)},
      cin          = {F100 / D192 / F045},
      ddc          = {500},
      cid          = {I:(DE-He78)F100-20160331 / I:(DE-He78)D192-20160331 /
                      I:(DE-He78)F045-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34686609},
      doi          = {10.1073/pnas.2115508118},
      url          = {https://inrepo02.dkfz.de/record/177192},
}