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000177205 041__ $$aEnglish
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000177205 1001_ $$aArpinati, Ludovica$$b0
000177205 245__ $$aTumor-Derived Factors Differentially Affect the Recruitment and Plasticity of Neutrophils.
000177205 260__ $$aBasel$$bMDPI$$c2021
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000177205 520__ $$aNeutrophils play a key role in cancer biology. In contrast to circulating normal-density neutrophils (NDN), the amount of low-density neutrophils (LDN) significantly increases with tumor progression. The correlation between these neutrophil subpopulations and intratumoral neutrophils (TANs) is still under debate. Using 4T1 (breast) and AB12 (mesothelioma) tumor models, we aimed to elucidate the source of TANs and to assess the mechanisms driving neutrophils' plasticity in cancer. Both NDN and LDN were found to migrate in response to CXCL1 and CXCL2 exposure, and co-infiltrate the tumor site ex vivo and in vivo, although LDN migration into the tumor was higher than NDN. Tumor-derived factors and chemokines, particularly CXCL1, were found to drive neutrophil phenotypical plasticity, inducing NDN to transition towards a low-density state (LD-NDN). LD-NDN appeared to differ from NDN by displaying a phenotypical profile similar to LDN in terms of nuclear morphology, surface receptor markers, decreased phagocytic abilities, and increased ROS production. Interestingly, all three subpopulations displayed comparable cytotoxic abilities towards tumor cells. Our data suggest that TANs originate from both LDN and NDN, and that a portion of LDN derives from NDN undergoing phenotypical changes. NDN plasticity resulted in a change in surface marker expression and functional activity, gaining characteristics of LDN.
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000177205 650_7 $$2Other$$aCXCL1
000177205 650_7 $$2Other$$aCXCR2 and CXCR4
000177205 650_7 $$2Other$$acancer immunology
000177205 650_7 $$2Other$$acell plasticity
000177205 650_7 $$2Other$$aneutrophils
000177205 7001_ $$aKaisar-Iluz, Naomi$$b1
000177205 7001_ $$aShaul, Merav E$$b2
000177205 7001_ $$0P:(DE-He78)b3119317bcde901d53a7f3cea31994b5$$aGroth, Christopher$$b3$$udkfz
000177205 7001_ $$0P:(DE-He78)38be34240daf8b47325afc7910e77f7b$$aUmansky, Viktor$$b4$$udkfz
000177205 7001_ $$aFridlender, Zvi G$$b5
000177205 773__ $$0PERI:(DE-600)2527080-1$$a10.3390/cancers13205082$$gVol. 13, no. 20, p. 5082 -$$n20$$p5082$$tCancers$$v13$$x2072-6694$$y2021
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