TY  - JOUR
AU  - Liu, Anthony P Y
AU  - Smith, Kyle S
AU  - Kumar, Rahul
AU  - Paul, Leena
AU  - Bihannic, Laure
AU  - Lin, Tong
AU  - Maass, Kendra K
AU  - Pajtler, Kristian W
AU  - Chintagumpala, Murali
AU  - Su, Jack M
AU  - Bouffet, Eric
AU  - Fisher, Michael J
AU  - Gururangan, Sridharan
AU  - Cohn, Richard
AU  - Hassall, Tim
AU  - Hansford, Jordan R
AU  - Klimo, Paul
AU  - Boop, Frederick A
AU  - Stewart, Clinton F
AU  - Harreld, Julie H
AU  - Merchant, Thomas E
AU  - Tatevossian, Ruth G
AU  - Neale, Geoffrey
AU  - Lear, Matthew
AU  - Klco, Jeffery M
AU  - Orr, Brent A
AU  - Ellison, David W
AU  - Gilbertson, Richard J
AU  - Onar-Thomas, Arzu
AU  - Gajjar, Amar
AU  - Robinson, Giles W
AU  - Northcott, Paul A
TI  - Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
JO  - Cancer cell
VL  - 39
IS  - 11
SN  - 1535-6108
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2021-02340
SP  - 1519-1530.e4
PY  - 2021
N1  - 2021 Nov 8;39(11):1519-1530.e4
AB  - Nearly one-third of children with medulloblastoma, a malignant embryonal tumor of the cerebellum, succumb to their disease. Conventional response monitoring by imaging and cerebrospinal fluid (CSF) cytology remains challenging, and a marker for measurable residual disease (MRD) is lacking. Here, we show the clinical utility of CSF-derived cell-free DNA (cfDNA) as a biomarker of MRD in serial samples collected from children with medulloblastoma (123 patients, 476 samples) enrolled on a prospective trial. Using low-coverage whole-genome sequencing, tumor-associated copy-number variations in CSF-derived cfDNA are investigated as an MRD surrogate. MRD is detected at baseline in 85
KW  - biomarkers (Other)
KW  - cell-free DNA (Other)
KW  - cerebrospinal fluid (Other)
KW  - childhood cancer (Other)
KW  - liquid biopsy (Other)
KW  - measurable residual disease (Other)
KW  - medulloblastoma (Other)
KW  - microscopic residual disease (Other)
KW  - minimal residual disease (Other)
KW  - relapse disease (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34678152
DO  - DOI:10.1016/j.ccell.2021.09.012
UR  - https://inrepo02.dkfz.de/record/177206
ER  -