%0 Journal Article
%A Longarino, Friderike
%A Tessonnier, Thomas
%A Mein, Stewart
%A Harrabi, Semi B
%A Debus, Jürgen
%A Stiller, Wolfram
%A Mairani, Andrea
%T Dual-layer spectral CT for proton, helium, and carbon ion beam therapy planning of brain tumors.
%J Journal of applied clinical medical physics
%V 23
%N 1
%@ 1526-9914
%C Reston, Va.
%I ACMP
%M DKFZ-2021-02388
%P e13465
%D 2022
%Z #EA:E050# / Volume23, Issue1 January 2022 e13465
%X Pretreatment computed tomography (CT) imaging is an essential component of the particle therapy treatment planning chain. Treatment planning and optimization with charged particles require accurate and precise estimations of ion beam range in tissues, characterized by the stopping power ratio (SPR). Reduction of range uncertainties arising from conventional CT-number-to-SPR conversion based on single-energy CT (SECT) imaging is of importance for improving clinical practice. Here, the application of a novel imaging and computational methodology using dual-layer spectral CT (DLCT) was performed toward refining patient-specific SPR estimates. A workflow for DLCT-based treatment planning was devised to evaluate SPR prediction for proton, helium, and carbon ion beam therapy planning in the brain. DLCT- and SECT-based SPR predictions were compared in homogeneous and heterogeneous anatomical regions. This study included eight patients scanned for diagnostic purposes with a DLCT scanner. For each patient, four different treatment plans were created, simulating tumors in different parts of the brain. For homogeneous anatomical regions, mean SPR differences of about 1
%K brain tumors (Other)
%K dual-layer spectral CT (Other)
%K ion beam therapy planning (Other)
%K range uncertainties (Other)
%K stopping power (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34724327
%R 10.1002/acm2.13465
%U https://inrepo02.dkfz.de/record/177254