TY  - JOUR
AU  - Longarino, Friderike
AU  - Tessonnier, Thomas
AU  - Mein, Stewart
AU  - Harrabi, Semi B
AU  - Debus, Jürgen
AU  - Stiller, Wolfram
AU  - Mairani, Andrea
TI  - Dual-layer spectral CT for proton, helium, and carbon ion beam therapy planning of brain tumors.
JO  - Journal of applied clinical medical physics
VL  - 23
IS  - 1
SN  - 1526-9914
CY  - Reston, Va.
PB  - ACMP
M1  - DKFZ-2021-02388
SP  - e13465
PY  - 2022
N1  - #EA:E050# / Volume23, Issue1 January 2022 e13465
AB  - Pretreatment computed tomography (CT) imaging is an essential component of the particle therapy treatment planning chain. Treatment planning and optimization with charged particles require accurate and precise estimations of ion beam range in tissues, characterized by the stopping power ratio (SPR). Reduction of range uncertainties arising from conventional CT-number-to-SPR conversion based on single-energy CT (SECT) imaging is of importance for improving clinical practice. Here, the application of a novel imaging and computational methodology using dual-layer spectral CT (DLCT) was performed toward refining patient-specific SPR estimates. A workflow for DLCT-based treatment planning was devised to evaluate SPR prediction for proton, helium, and carbon ion beam therapy planning in the brain. DLCT- and SECT-based SPR predictions were compared in homogeneous and heterogeneous anatomical regions. This study included eight patients scanned for diagnostic purposes with a DLCT scanner. For each patient, four different treatment plans were created, simulating tumors in different parts of the brain. For homogeneous anatomical regions, mean SPR differences of about 1
KW  - brain tumors (Other)
KW  - dual-layer spectral CT (Other)
KW  - ion beam therapy planning (Other)
KW  - range uncertainties (Other)
KW  - stopping power (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34724327
DO  - DOI:10.1002/acm2.13465
UR  - https://inrepo02.dkfz.de/record/177254
ER  -