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@ARTICLE{Klimek:177323,
author = {M. Klimek and G. Büchele and M. Rehm and J. Beyersmann and
K.-P. Günther and H. Brenner$^*$ and T. Stürmer and R. E.
Brenner and D. Rothenbacher},
title = {{L}ong-term mortality of patients with osteoarthritis after
joint replacement: {P}rognostic value of pre- and
postoperative pain and function.},
journal = {Arthritis care $\&$ research},
volume = {75},
number = {4},
issn = {0893-7524},
address = {New York, NY [u.a.]},
publisher = {Wiley},
reportid = {DKFZ-2021-02435},
pages = {869-875},
year = {2023},
note = {2023 Apr;75(4):869-875},
abstract = {To investigate whether osteoarthritis (OA)-specific
assessment values (i.e. Western Ontario and McMaster
University Osteoarthritis Index [WOMAC]) and generic pain
and function (visual analog scale [VAS], Hanover
Functionality Status Questionnaire [FFbH]) measured before
and 12 months after arthroplasty are associated with the
risk of long-term mortality in a cohort of patients with
advanced OA of the hip or knee.The Ulm Osteoarthritis Study
was a prospective cohort study of OA patients with
unilateral total hip or knee replacement between January
1995 and December 1996. Correlation coefficients were
calculated to describe the agreement between the different
assessments. Mortality was assessed during the follow-up
period (last update: July 2019). Cox proportional regression
models were used to estimate hazard ratios (HRs) for
mortality after adjusting for covariates.Arthroplasty was
accompanied by a clear reduction in pain and improved
function throughout all assessments in the 706 included
patients. The results of the adjusted Cox models showed no
relationship between baseline and follow-up joint-specific
WOMAC assessments and long-term mortality. However, an
independent increased risk of mortality was found with
generic function assessments. In the final adjusted model,
the HR for the 12-month follow-up value was 1.79 $(95\%$
confidence interval, 1.24-2.60) in the group with clinically
relevant impairment versus the reference group.Poor function
based on the generic assessment was associated with
increased long-term mortality, suggesting that functional
impairments in daily life activities may be more important
for long-term survival than OA-specific impairments in this
patient group. This article is protected by copyright. All
rights reserved.},
cin = {C070},
ddc = {610},
cid = {I:(DE-He78)C070-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34738320},
doi = {10.1002/acr.24808},
url = {https://inrepo02.dkfz.de/record/177323},
}