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@ARTICLE{Bostel:177326,
      author       = {T. Bostel$^*$ and S. Akbaba$^*$ and D. Wollschläger and T.
                      Klodt$^*$ and L. Oebel$^*$ and A. Mayer$^*$ and S.
                      Drabke$^*$ and T. Sprave$^*$ and J. Debus$^*$ and R.
                      Förster and H. Rief and A. Rühle$^*$ and A.-L. Grosu$^*$
                      and H. Schmidberger$^*$ and N. Nicolay$^*$},
      title        = {{C}omparative {A}nalyses of {T}wo {E}stablished {S}cores to
                      {A}ssess the {S}tability of {S}pinal {B}one {M}etastases
                      {B}efore and {A}fter {P}alliative {R}adiotherapy.},
      journal      = {Frontiers in oncology},
      volume       = {11},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2021-02438},
      pages        = {753768},
      year         = {2021},
      note         = {#LA:E055#},
      abstract     = {To compare two validated spinal instability scores
                      regarding the stabilizing effects and skeletal-related
                      events (SREs) of palliative radiotherapy (RT) in patients
                      with spinal bone metastases (SBM).Two hundred eighty-two
                      osteolytic SBM of lung or breast cancer patients were
                      analyzed for stability before and following RT based on the
                      Spinal Instability Neoplastic Score (SINS) or the Taneichi
                      score. Score concordance was quantified by absolute
                      agreement and Cohen's kappa coefficient. SREs were defined
                      as fractures or local progression after RT. OS was
                      quantified as the time between the start of RT and death
                      from any cause.At 3 and 6 months after RT, 35 and $50\%$ of
                      initially unstable SBM were re-stabilized according to SINS
                      in patients still alive. Corresponding Taneichi score-based
                      stabilization proportions were 25 and $46\%,$ respectively.
                      Comparison of both stability scores showed high absolute
                      agreement for all time-points (range $71-78\%,$ kappa range
                      0.35-0.44). SRE occurred more frequently in initially
                      unstable SBM compared to stable SBM according to SINS (14
                      vs. $5\%),$ but no such association could be shown for the
                      Taneichi-based instability criterion. Poor general condition
                      of patients was negatively associated with SINS-measured
                      re-stabilization after 6 months, but no predictive factor
                      for re-stabilization could be found for the Taneichi
                      score.Despite the relatively high agreement between both
                      stabilization scores, the SINS should be considered the
                      standard for future studies on the stabilization effects of
                      RT in SBM.},
      keywords     = {SINS (Other) / instability (Other) / radiotherapy (Other) /
                      skeletal-related events (Other) / spinal bone metastases
                      (Other)},
      cin          = {FM01 / FR01 / HD01 / E050 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331 / I:(DE-He78)FR01-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)E050-20160331 /
                      I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34737961},
      pmc          = {pmc:PMC8562722},
      doi          = {10.3389/fonc.2021.753768},
      url          = {https://inrepo02.dkfz.de/record/177326},
}