%0 Journal Article
%A Jenseit, Anne Lena
%A Camgoz, Aylin
%A Pfister, Stefan M
%A Kool, Marcel
%T EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma.
%J Acta neuropathologica
%V 143
%N 1
%@ 1432-0533
%C Heidelberg
%I Springer
%M DKFZ-2021-02473
%P 1-13
%D 2022
%Z #EA:B062#LA:B062# / 2022 Jan;143(1):1-13
%X Ependymomas (EPN) are tumors of the central nervous system (CNS) that can arise in the supratentorial brain (ST-EPN), hindbrain or posterior fossa (PF-EPN) or anywhere in the spinal cord (SP-EPN), both in children and adults. Molecular profiling studies have identified distinct groups and subtypes in each of these anatomical compartments. In this review, we give an overview on recent findings and new insights what is driving PFA ependymomas, which is the most common group. PFA ependymomas are characterized by a young median age at diagnosis, an overall balanced genome and a bad clinical outcome (56
%K DMG (Other)
%K EZHIP (Other)
%K H3K27M (Other)
%K H3K27me3 (Other)
%K PFA ependymoma (Other)
%K PRC2 (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34762160
%R 10.1007/s00401-021-02382-4
%U https://inrepo02.dkfz.de/record/177381