TY  - JOUR
AU  - Jenseit, Anne Lena
AU  - Camgoz, Aylin
AU  - Pfister, Stefan M
AU  - Kool, Marcel
TI  - EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma.
JO  - Acta neuropathologica
VL  - 143
IS  - 1
SN  - 1432-0533
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2021-02473
SP  - 1-13
PY  - 2022
N1  - #EA:B062#LA:B062# / 2022 Jan;143(1):1-13
AB  - Ependymomas (EPN) are tumors of the central nervous system (CNS) that can arise in the supratentorial brain (ST-EPN), hindbrain or posterior fossa (PF-EPN) or anywhere in the spinal cord (SP-EPN), both in children and adults. Molecular profiling studies have identified distinct groups and subtypes in each of these anatomical compartments. In this review, we give an overview on recent findings and new insights what is driving PFA ependymomas, which is the most common group. PFA ependymomas are characterized by a young median age at diagnosis, an overall balanced genome and a bad clinical outcome (56
KW  - DMG (Other)
KW  - EZHIP (Other)
KW  - H3K27M (Other)
KW  - H3K27me3 (Other)
KW  - PFA ependymoma (Other)
KW  - PRC2 (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34762160
DO  - DOI:10.1007/s00401-021-02382-4
UR  - https://inrepo02.dkfz.de/record/177381
ER  -