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000177382 1001_ $$aKhandanpour, Cyrus$$b0
000177382 245__ $$aPrevalence of the GFI1-36N SNP in Multiple Myeloma Patients and Its Impact on the Prognosis.
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000177382 520__ $$aTranscription factor Growth Factor Independence 1 (GFI1) regulates the expression of genes important for survival, proliferation and differentiation of hematopoietic cells. A single nucleotide polymorphism (SNP) variant of GFI1 (GFI1-36N: serine replaced by asparagine at position 36), has a prevalence of 5-7% among healthy Caucasians and 10-15% in patients with myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) predisposing GFI-36N carriers to these diseases. Since GFI1 is implicated in B cell maturation and plasma cell (PC) development, we examined its prevalence in patients with multiple myeloma (MM), a haematological malignancy characterized by expansion of clonal PCs. Strikingly, as in MDS and AML, we found that the GFI1-36N had a higher prevalence among MM patients compared to the controls. In subgroup analyses, GFI1-36N correlates to a shorter overall survival of MM patients characterized by the presence of t(4;14) translocation and gain of 1q21 (≤3 copies). MM patients carrying gain of 1q21 (≥3 copies) demonstrated poor progression free survival. Furthermore, gene expression analysis implicated a role for GFI1-36N in epigenetic regulation and metabolism, potentially promoting the initiation and progression of MM.
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000177382 650_7 $$2Other$$aGfi1
000177382 650_7 $$2Other$$aSNP variant
000177382 650_7 $$2Other$$amultiple myeloma
000177382 650_7 $$2Other$$aprevalance
000177382 650_7 $$2Other$$aprognosis
000177382 7001_ $$aEisfeld, Christine$$b1
000177382 7001_ $$aNimmagadda, Subbaiah Chary$$b2
000177382 7001_ $$aRaab, Marc S$$b3
000177382 7001_ $$aWeinhold, Niels$$b4
000177382 7001_ $$aSeckinger, Anja$$b5
000177382 7001_ $$aHose, Dirk$$b6
000177382 7001_ $$aJauch, Anna$$b7
000177382 7001_ $$0P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aFörsti, Asta$$b8$$udkfz
000177382 7001_ $$0P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aHemminki, Kari$$b9$$udkfz
000177382 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, Thomas$$b10$$udkfz
000177382 7001_ $$0P:(DE-He78)fae4f3c76bbbd2fc21dd920b46945d42$$aHummel, Manuela$$b11
000177382 7001_ $$aLenz, Georg$$b12
000177382 7001_ $$aGoldschmidt, Hartmut$$b13
000177382 7001_ $$aHuhn, Stefanie$$b14
000177382 773__ $$0PERI:(DE-600)2649216-7$$a10.3389/fonc.2021.757664$$gVol. 11, p. 757664$$p757664$$tFrontiers in oncology$$v11$$x2234-943X$$y2021
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