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000177394 1001_ $$00000-0002-1065-2198$$aCamargo, M Constanza$$b0
000177394 245__ $$aUrinary estrogen metabolites and gastric cancer risk among postmenopausal women.
000177394 260__ $$aMedford, MA$$bWiley$$c2022
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000177394 500__ $$a2022 Jul;5(7):e1574
000177394 520__ $$aThe overall incidence of gastric cancer in women is half that in men for most global populations. Sex hormone pathways may be involved in carcinogenesis and estrogens have been postulated to protect women against gastric cancer.To evaluate associations of gastric cancer with estrogen metabolites in postmenopausal women.We performed an analysis of 233 gastric cancer cases and 281 age-matched controls from three prospective cohorts and two case-control studies of early-stage gastric cancer, mainly conducted in high-risk Asian populations. Fifteen estrogen-parent (estrone and estradiol) and -metabolite analytes (2-hydroxyestrone, 2-hydroxyestradiol, 2-hydroxyestrone-3-methyl ether, 4-hydroxyestrone; 4-methoxyestrone, 4-methoxyestradiol, 2-methoxyestrone, 2-methoxyestradiol, estriol, 16α-hydroxyestrone, 16-ketoestradiol, 16-epiestriol, and 17-epiestriol) were measured in spot urines using liquid chromatography-tandem mass spectrometry. Odds ratios for association with each marker were estimated by logistic regression. Heterogeneity was assessed by Cochran's Q test. Study-specific odds ratios were pooled by fixed-effects meta-analysis. Urinary levels of estrogen-related molecules were not associated with gastric cancer (adjusted odds ratios ranged from 0.87 to 1.27; p-values >.05), with low between-study heterogeneity (p-values >.1) for all but two metabolites (2-hydroxyestrone-3-methyl ether and 2-methoxyestradiol).To date, this is the first comprehensive assessment of endogenous estrogens with gastric cancer risk in women. Estrogens do not appear to have an etiologic role in gastric cancer risk among postmenopausal women. Given the complex network of sex steroid hormones and their extreme variation over the lifespan, further evaluation of this hypothesis is warranted.
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000177394 650_7 $$2Other$$aestradiol
000177394 650_7 $$2Other$$aestrogens
000177394 650_7 $$2Other$$aestrone
000177394 650_7 $$2Other$$agastric cancer
000177394 650_7 $$2Other$$asex hormones
000177394 7001_ $$00000-0002-9412-2871$$aSong, Minkyo$$b1
000177394 7001_ $$aXu, Xia$$b2
000177394 7001_ $$aZhao, Isaac$$b3
000177394 7001_ $$aSampson, Joshua N$$b4
000177394 7001_ $$aEtemadi, Arash$$b5
000177394 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b6$$udkfz
000177394 7001_ $$aLee, Hwi-Won$$b7
000177394 7001_ $$aTrabert, Britton$$b8
000177394 7001_ $$0P:(DE-He78)53e1a2846c69064e27790dbf349ccaec$$aHolleczek, Bernd$$b9$$udkfz
000177394 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b10$$udkfz
000177394 7001_ $$aSpaid, Kathleen$$b11
000177394 7001_ $$aDawsey, Sanford M$$b12
000177394 7001_ $$00000-0003-4080-0494$$aLee, Sangjun$$b13
000177394 7001_ $$aShimura, Takaya$$b14
000177394 7001_ $$aPark, Sue K$$b15
000177394 7001_ $$aMalekzadeh, Reza$$b16
000177394 7001_ $$aKang, Daehee$$b17
000177394 7001_ $$aRabkin, Charles S$$b18
000177394 773__ $$0PERI:(DE-600)2920367-3$$a10.1002/cnr2.1574$$n7$$pe1574$$tCancer reports$$v5$$x2573-8348$$y2022
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