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@ARTICLE{Camargo:177394,
      author       = {M. C. Camargo and M. Song and X. Xu and I. Zhao and J. N.
                      Sampson and A. Etemadi and H. Brenner$^*$ and H.-W. Lee and
                      B. Trabert and B. Holleczek$^*$ and B. Schöttker$^*$ and K.
                      Spaid and S. M. Dawsey and S. Lee and T. Shimura and S. K.
                      Park and R. Malekzadeh and D. Kang and C. S. Rabkin},
      title        = {{U}rinary estrogen metabolites and gastric cancer risk
                      among postmenopausal women.},
      journal      = {Cancer reports},
      volume       = {5},
      number       = {7},
      issn         = {2573-8348},
      address      = {Medford, MA},
      publisher    = {Wiley},
      reportid     = {DKFZ-2021-02486},
      pages        = {e1574},
      year         = {2022},
      note         = {2022 Jul;5(7):e1574},
      abstract     = {The overall incidence of gastric cancer in women is half
                      that in men for most global populations. Sex hormone
                      pathways may be involved in carcinogenesis and estrogens
                      have been postulated to protect women against gastric
                      cancer.To evaluate associations of gastric cancer with
                      estrogen metabolites in postmenopausal women.We performed an
                      analysis of 233 gastric cancer cases and 281 age-matched
                      controls from three prospective cohorts and two case-control
                      studies of early-stage gastric cancer, mainly conducted in
                      high-risk Asian populations. Fifteen estrogen-parent
                      (estrone and estradiol) and -metabolite analytes
                      (2-hydroxyestrone, 2-hydroxyestradiol,
                      2-hydroxyestrone-3-methyl ether, 4-hydroxyestrone;
                      4-methoxyestrone, 4-methoxyestradiol, 2-methoxyestrone,
                      2-methoxyestradiol, estriol, 16α-hydroxyestrone,
                      16-ketoestradiol, 16-epiestriol, and 17-epiestriol) were
                      measured in spot urines using liquid chromatography-tandem
                      mass spectrometry. Odds ratios for association with each
                      marker were estimated by logistic regression. Heterogeneity
                      was assessed by Cochran's Q test. Study-specific odds ratios
                      were pooled by fixed-effects meta-analysis. Urinary levels
                      of estrogen-related molecules were not associated with
                      gastric cancer (adjusted odds ratios ranged from 0.87 to
                      1.27; p-values >.05), with low between-study heterogeneity
                      (p-values >.1) for all but two metabolites
                      (2-hydroxyestrone-3-methyl ether and 2-methoxyestradiol).To
                      date, this is the first comprehensive assessment of
                      endogenous estrogens with gastric cancer risk in women.
                      Estrogens do not appear to have an etiologic role in gastric
                      cancer risk among postmenopausal women. Given the complex
                      network of sex steroid hormones and their extreme variation
                      over the lifespan, further evaluation of this hypothesis is
                      warranted.},
      keywords     = {estradiol (Other) / estrogens (Other) / estrone (Other) /
                      gastric cancer (Other) / sex hormones (Other)},
      cin          = {C120 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34766475},
      doi          = {10.1002/cnr2.1574},
      url          = {https://inrepo02.dkfz.de/record/177394},
}