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@PHDTHESIS{Jansen:177442,
      author       = {J. Jansen$^*$},
      title        = {{O}xygen {E}ffects in ({FLASH}-) {R}adiotherapy on a
                      {R}adiochemical and {G}enetic {L}evel},
      school       = {Universität Heidelberg},
      type         = {Dissertation},
      reportid     = {DKFZ-2021-02534},
      year         = {2021},
      note         = {Corresponding author J. Seco; Dissertation, Universität
                      Heidelberg, 2021},
      abstract     = {In radiotherapy, oxygen acts as strong radiosensitizer and
                      alters cellular responseto radiation drastically.
                      Especially, the e‚ect of the so-called FLASH
                      radiotherapy,which applies high dose rates above 40 Gy/s to
                      spare healthy tissue from radiationdamage, is inƒuenced by
                      oxygen. At high O2levels the protective e‚ect of FLASH
                      isdecreased in vivo. ‘e underlying mechanisms are not
                      completely understood yet.In this thesis, oxygen e‚ects
                      were investigated on (i) a radiochemical level by oxygen
                      depletion measurements in water phantoms and together with
                      cancer cells, (ii)on a genetic level developing a novel
                      analysis method on gene expression pa‹ernsand (iii) on a
                      mechanistic, radical scavenging level by modulating cellular
                      defense.It was found, that a popular hypothesis for
                      explaining the FLASH e‚ect, the oxygendepletion hypothesis,
                      cannot be solely responsible for the observed altered
                      cellularresponse a‰er FLASH through radiation induced
                      hypoxia alone. However, radicalconcentrations are highly
                      dependent on dose rate and beam pulse structure
                      implyingpotential biological impact. Radical scavenging
                      systems in cells were found to be altered using
                      SOD-mimicking CuL/FeL compounds leading to a decrease of
                      metastaticpotential. ‘e results strengthen the link between
                      FLASH e‚ects and radical levels,inƒuenced by radical
                      scavenging systems in cancer cells and oxygen conditions.},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)11},
      url          = {https://inrepo02.dkfz.de/record/177442},
}