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| 001 | 177442 | ||
| 005 | 20240229133740.0 | ||
| 037 | _ | _ | |a DKFZ-2021-02534 |
| 100 | 1 | _ | |a Jansen, Jeannette |0 P:(DE-He78)02e29e2d540ff21d777f3a03ec9f5ade |b 0 |g female |
| 245 | _ | _ | |a Oxygen Effects in (FLASH-) Radiotherapy on a Radiochemical and Genetic Level |
| 260 | _ | _ | |c 2021 |
| 336 | 7 | _ | |a Output Types/Dissertation |2 DataCite |
| 336 | 7 | _ | |a DISSERTATION |2 ORCID |
| 336 | 7 | _ | |a PHDTHESIS |2 BibTeX |
| 336 | 7 | _ | |a Thesis |0 2 |2 EndNote |
| 336 | 7 | _ | |a Dissertation / PhD Thesis |b phd |m phd |0 PUB:(DE-HGF)11 |s 1637151973_22468 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a doctoralThesis |2 DRIVER |
| 500 | _ | _ | |a Corresponding author J. Seco |
| 502 | _ | _ | |a Dissertation, Universität Heidelberg, 2021 |c Universität Heidelberg |b Dissertation |g Fakultät für Physik und Astronomie |
| 520 | _ | _ | |a In radiotherapy, oxygen acts as strong radiosensitizer and alters cellular responseto radiation drastically. Especially, the eect of the so-called FLASH radiotherapy,which applies high dose rates above 40 Gy/s to spare healthy tissue from radiationdamage, is inuenced by oxygen. At high O2levels the protective eect of FLASH isdecreased in vivo. e underlying mechanisms are not completely understood yet.In this thesis, oxygen eects were investigated on (i) a radiochemical level by oxygen depletion measurements in water phantoms and together with cancer cells, (ii)on a genetic level developing a novel analysis method on gene expression paernsand (iii) on a mechanistic, radical scavenging level by modulating cellular defense.It was found, that a popular hypothesis for explaining the FLASH eect, the oxygendepletion hypothesis, cannot be solely responsible for the observed altered cellularresponse aer FLASH through radiation induced hypoxia alone. However, radicalconcentrations are highly dependent on dose rate and beam pulse structure implyingpotential biological impact. Radical scavenging systems in cells were found to be altered using SOD-mimicking CuL/FeL compounds leading to a decrease of metastaticpotential. e results strengthen the link between FLASH eects and radical levels,inuenced by radical scavenging systems in cancer cells and oxygen conditions. |
| 536 | _ | _ | |a 315 - Bildgebung und Radioonkologie (POF4-315) |0 G:(DE-HGF)POF4-315 |c POF4-315 |f POF IV |x 0 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:177442 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)02e29e2d540ff21d777f3a03ec9f5ade |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-315 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Bildgebung und Radioonkologie |x 0 |
| 914 | 1 | _ | |y 2021 |
| 920 | 1 | _ | |0 I:(DE-He78)E041-20160331 |k E041 |l E041 Medizinische Physik in der Radioonkologie |x 0 |
| 980 | _ | _ | |a phd |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)E041-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
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