000177443 001__ 177443
000177443 005__ 20240229133740.0
000177443 037__ $$aDKFZ-2021-02535
000177443 1001_ $$0P:(DE-He78)15d0e694db442a1762a025b802a56f75$$aHanley, Rachel$$b0$$gfemale
000177443 245__ $$aStudying radiation generated DNA damage and how it is affected by oxygen and cellular metabolism
000177443 260__ $$c2021
000177443 3367_ $$2DataCite$$aOutput Types/Dissertation
000177443 3367_ $$2ORCID$$aDISSERTATION
000177443 3367_ $$2BibTeX$$aPHDTHESIS
000177443 3367_ $$02$$2EndNote$$aThesis
000177443 3367_ $$0PUB:(DE-HGF)11$$2PUB:(DE-HGF)$$aDissertation / PhD Thesis$$bphd$$mphd$$s1637151865_7660
000177443 3367_ $$2DRIVER$$adoctoralThesis
000177443 500__ $$aCorresponding author J. Seco
000177443 502__ $$aDissertation, Universität Heidelberg, 2021$$bDissertation$$cUniversität Heidelberg$$gFakultät für Physik und Astronomie
000177443 520__ $$aCancer is one of the leading causes of death in the world and is routinely treated with radiotherapy. Radiation causes cellular damage by interacting either directly with DNA or indirectly via the formation of reactive oxygen species (ROS) resulting in double strand breaks (DSBs) and/or genomic instability. However, the efficacy of the radiation depends largely on the tumor microenvironment. Tumors tend to form hypoxic (low oxygen) regions due to their highly proliferative characteristics but are biologically programmed to adapt to these low oxygen situations via metabolic alterations to maintain their homeostasis. This can be problematic, however, as it can have a strong negative influence on the biological effects of ionizing radiation by increasing cellular radio-resistance and thereby reducing the therapy outcome (1,2).There are therefore two aims to this dissertation: 1. Analyse the indirect DNA damage of radiation on different non-small lung cancer cell lines (NSCLC) and correlate with nuclear and cytosolic radiation-induced ROS.2. Study how these adaptive responses to tumor hypoxia contribute to radio-resistance for a variety of different cancer cell lines and thus provide potential metabolic predictors to therapy outcome.
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000177443 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)15d0e694db442a1762a025b802a56f75$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000177443 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000177443 9141_ $$y2021
000177443 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
000177443 980__ $$aphd
000177443 980__ $$aVDB
000177443 980__ $$aI:(DE-He78)E041-20160331
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