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@PHDTHESIS{Hanley:177443,
      author       = {R. Hanley$^*$},
      title        = {{S}tudying radiation generated {DNA} damage and how it is
                      affected by oxygen and cellular metabolism},
      school       = {Universität Heidelberg},
      type         = {Dissertation},
      reportid     = {DKFZ-2021-02535},
      year         = {2021},
      note         = {Corresponding author J. Seco; Dissertation, Universität
                      Heidelberg, 2021},
      abstract     = {Cancer is one of the leading causes of death in the world
                      and is routinely treated with radiotherapy. Radiation causes
                      cellular damage by interacting either directly with DNA or
                      indirectly via the formation of reactive oxygen species
                      (ROS) resulting in double strand breaks (DSBs) and/or
                      genomic instability. However, the efficacy of the radiation
                      depends largely on the tumor microenvironment. Tumors tend
                      to form hypoxic (low oxygen) regions due to their highly
                      proliferative characteristics but are biologically
                      programmed to adapt to these low oxygen situations via
                      metabolic alterations to maintain their homeostasis. This
                      can be problematic, however, as it can have a strong
                      negative influence on the biological effects of ionizing
                      radiation by increasing cellular radio-resistance and
                      thereby reducing the therapy outcome (1,2).There are
                      therefore two aims to this dissertation: 1. Analyse the
                      indirect DNA damage of radiation on different non-small lung
                      cancer cell lines (NSCLC) and correlate with nuclear and
                      cytosolic radiation-induced ROS.2. Study how these adaptive
                      responses to tumor hypoxia contribute to radio-resistance
                      for a variety of different cancer cell lines and thus
                      provide potential metabolic predictors to therapy outcome.},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)11},
      url          = {https://inrepo02.dkfz.de/record/177443},
}