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@INPROCEEDINGS{Genard:177445,
      author       = {G. Genard$^*$ and F. Pagliari$^*$ and J. Seco$^*$},
      title        = {{C}arbon-ion therapy for immune activation in solid cancer:
                      focus on small extracellular vesicles},
      reportid     = {DKFZ-2021-02537},
      year         = {2021},
      abstract     = {Since the immune system is recognized as a determinant
                      factor for tumor growth, most of new anticancer therapeutic
                      strategies have been orientated to target immune cells.
                      Interestingly, radiotherapy (RT) has in some instances the
                      potential to act as an adjuvant for the tumor immune system.
                      Some technical advances in radiotherapy has revolutionized
                      the clinical care of patients, such as the use of charged
                      particles. Charged particles allow a better sparing of
                      healthy tissues and has a higher relative biological
                      effectiveness than conventional RT (X-rays and γ-rays). In
                      this context, recent works reported a broader activation of
                      the immune system in patients and tumor mouse models with
                      charged particle therapy, and more specifically with carbon
                      ion therapy, as compared to X-rays. However, to date, no
                      study has deciphered the immune cellular and molecular
                      changes mediated by charged particle therapy in the tumor
                      microenvironment. For conventional RT (X-rays), it is known
                      that the immune response can be mediated by a crosstalk
                      between cancer cells and immune cells, involving small
                      extracellular vesicles (sEVs), also named exosomes, which
                      have the potential to travel through the body to reach
                      different targeted cells. In this project, we decipher key
                      biological questions: How does carbon ion therapy influence
                      the immune response in cancer and how does this therapy
                      affect sEV cargos in order to better understand the immune
                      response triggered by carbon ions and possibly to associate
                      radiotherapy to new immune-targeted drugs. Finally,
                      diagnostic and prognostic factors are also planned to be
                      evaluated on patients, treated at the Heidelberg Ion Therapy
                      (HIT) center (Carbon ions) or Heidelberg hospital (X-rays).},
      month         = {Sep},
      date          = {2021-09-14},
      organization  = {The 5th Edition of the International
                       Conference on Immunotherapy
                       Radiotherapy Combinations, Paris
                       (France), 14 Sep 2021 - 17 Sep 2021},
      subtyp        = {Invited},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://inrepo02.dkfz.de/record/177445},
}