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001     177445
005     20240229133740.0
037 _ _ |a DKFZ-2021-02537
100 1 _ |a Genard, Geraldine
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111 2 _ |a The 5th Edition of the International Conference on Immunotherapy Radiotherapy Combinations
|c Paris
|d 2021-09-14 - 2021-09-17
|w France
245 _ _ |a Carbon-ion therapy for immune activation in solid cancer: focus on small extracellular vesicles
260 _ _ |c 2021
336 7 _ |a Conference Paper
|0 33
|2 EndNote
336 7 _ |a Other
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336 7 _ |a INPROCEEDINGS
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336 7 _ |a Conference Presentation
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520 _ _ |a Since the immune system is recognized as a determinant factor for tumor growth, most of new anticancer therapeutic strategies have been orientated to target immune cells. Interestingly, radiotherapy (RT) has in some instances the potential to act as an adjuvant for the tumor immune system. Some technical advances in radiotherapy has revolutionized the clinical care of patients, such as the use of charged particles. Charged particles allow a better sparing of healthy tissues and has a higher relative biological effectiveness than conventional RT (X-rays and γ-rays). In this context, recent works reported a broader activation of the immune system in patients and tumor mouse models with charged particle therapy, and more specifically with carbon ion therapy, as compared to X-rays. However, to date, no study has deciphered the immune cellular and molecular changes mediated by charged particle therapy in the tumor microenvironment. For conventional RT (X-rays), it is known that the immune response can be mediated by a crosstalk between cancer cells and immune cells, involving small extracellular vesicles (sEVs), also named exosomes, which have the potential to travel through the body to reach different targeted cells. In this project, we decipher key biological questions: How does carbon ion therapy influence the immune response in cancer and how does this therapy affect sEV cargos in order to better understand the immune response triggered by carbon ions and possibly to associate radiotherapy to new immune-targeted drugs. Finally, diagnostic and prognostic factors are also planned to be evaluated on patients, treated at the Heidelberg Ion Therapy (HIT) center (Carbon ions) or Heidelberg hospital (X-rays).
536 _ _ |a 315 - Bildgebung und Radioonkologie (POF4-315)
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700 1 _ |a Pagliari, Francesca
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700 1 _ |a Seco, Joao
|0 P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe
|b 2
|e Corresponding author
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909 C O |o oai:inrepo02.dkfz.de:177445
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910 1 _ |a Deutsches Krebsforschungszentrum
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910 1 _ |a Deutsches Krebsforschungszentrum
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910 1 _ |a Deutsches Krebsforschungszentrum
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913 1 _ |a DE-HGF
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|v Bildgebung und Radioonkologie
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914 1 _ |y 2021
920 1 _ |0 I:(DE-He78)E041-20160331
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