000177450 001__ 177450
000177450 005__ 20240229133740.0
000177450 037__ $$aDKFZ-2021-02542
000177450 1001_ $$0P:(DE-HGF)0$$aOchoa Parra, Pamela$$b0
000177450 245__ $$aEnd-to-end range prediction forheavier ion radiation therapy basedon Monte Carlo simulations
000177450 260__ $$c2021
000177450 3367_ $$2DataCite$$aOutput Types/Supervised Student Publication
000177450 3367_ $$02$$2EndNote$$aThesis
000177450 3367_ $$2BibTeX$$aMASTERSTHESIS
000177450 3367_ $$2DRIVER$$amasterThesis
000177450 3367_ $$0PUB:(DE-HGF)19$$2PUB:(DE-HGF)$$aMaster Thesis$$bmaster$$mmaster$$s1637151662_27175
000177450 3367_ $$2ORCID$$aSUPERVISED_STUDENT_PUBLICATION
000177450 500__ $$aCorresponding author J. Seco
000177450 502__ $$aMasterarbeit, Universidad Nacional de Colombia, 2021$$bMasterarbeit$$cUniversidad Nacional de Colombia$$gFacultad de Ciencias Departamento de F´ısica
000177450 520__ $$aThe presence of range uncertainties in charged particle therapy with light ions (CPT)requires the employment of safety margins during treatment planning. These affecttreatment quality, not allowing to fully exploit the dosimetric potential of CPT. CPT ischaracterized by an escalation of the dose deposition towards the end of the range of theprimary particles followed by a steep decrease to a low-dose tail (Bragg Peak). Thedimension of the safety margins can be reduced by adopting novel methods to verify theprimary particle ranges in patients. Non-invasive in vivo monitoring can be performed bydetecting secondary radiation emitted from the patient after nuclear interactions of thebeam with tissue. Among secondary radiation, the gamma de-excitation of nuclei has thefavorable properties of an instantaneous emission and a discrete energy spectrum, whichallows performing range control through prompt gamma spectroscopy (PGS). Recentstudies demonstrated the capabilities of PGS for online range verification for protonbeams. Along with the experimental developments, a critical step towards the applicationof PGS for range control during patient treatments is the implementation of the promptgamma generation in a treatment planning system. The comparison of the experimentaldata acquired during the treatment to the predicted spectral features is the fundamentalstep to achieve absolute range measurements in vivo. The project aimed to obtain a fullyintegrated method to perform end-to-end range predictions in anthropomorphic phantoms.In the first stage, a Monte Carlo simulation was conducted to obtain the values of thecross-section for 19 prompt gamma-ray lines from proton-nuclear interactions with 16O and12C. The central part of the project included the implementation of the cross-sections inthe research treatment planning system matRad.
000177450 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000177450 909CO $$ooai:inrepo02.dkfz.de:177450$$pVDB
000177450 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000177450 9141_ $$y2021
000177450 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
000177450 980__ $$amaster
000177450 980__ $$aVDB
000177450 980__ $$aI:(DE-He78)E041-20160331
000177450 980__ $$aUNRESTRICTED