000177455 001__ 177455
000177455 005__ 20240229133741.0
000177455 037__ $$aDKFZ-2021-02547
000177455 1001_ $$0P:(DE-He78)c05a55723806b3aa6693a6c5a70c73f0$$aBaltazar, Filipa$$b0
000177455 245__ $$aFLASH optimization for multi-beam proton therapy
000177455 260__ $$c2021
000177455 3367_ $$2DataCite$$aOutput Types/Supervised Student Publication
000177455 3367_ $$02$$2EndNote$$aThesis
000177455 3367_ $$2BibTeX$$aMASTERSTHESIS
000177455 3367_ $$2DRIVER$$amasterThesis
000177455 3367_ $$0PUB:(DE-HGF)19$$2PUB:(DE-HGF)$$aMaster Thesis$$bmaster$$mmaster$$s1637151278_27175
000177455 3367_ $$2ORCID$$aSUPERVISED_STUDENT_PUBLICATION
000177455 500__ $$aCorresponding author: J. Seco
000177455 502__ $$aMasterarbeit, IST, University of Lisbon, 2021$$bMasterarbeit$$cIST, University of Lisbon$$gFaculty of Biomedical Engineering
000177455 520__ $$aRadiotherapy is a balancing act between maximizing tumor control and minimizing radiation-inducedtoxicity. FLASH radiotherapy has shown promising results in reducing the healthy tissue damage for thesame level of tumor toxicity. This work aims at the development of a treatment plan strategy for FLASHradiotherapy, considering multiple proton beams. In order to allow that, we must divide the target indifferent regions. Each region is irradiated with either FLASH or conventional beams, and then webring the different irradiated regions all together in an optimized stitching geometry. Different tools andmethods of incorporating dose rate into treatment planning were explored. Particularly, both sequentialand simultaneous dose and dose rate optimization techniques were studied, and specific treatment planswere implemented. Results showed the potential of the stitching geometry in accommodating multipleFLASH beams in homogeneous target irradiation, while preventing the creation of overdosing scenarios.For a treatment plan considering one FLASH and three conventional beams whose dose and dose ratewere sequentially optimized, a homogeneity index of 0.14 and a D2% equivalent to 109.5% of the totalprescribed dose were achieved. For the simultaneous optimization treatment plans, preconditioningproblems impacted the solution found by the optimizer, and homogeneity indexes of 0.73 and 0.90 werecomputed for plans considering two FLASH and one conventional beams. Nevertheless, the differenttests performed with this optimization strategy illustrate its potential and motivate further research.
000177455 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000177455 909CO $$ooai:inrepo02.dkfz.de:177455$$pVDB
000177455 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c05a55723806b3aa6693a6c5a70c73f0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000177455 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000177455 9141_ $$y2021
000177455 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
000177455 980__ $$amaster
000177455 980__ $$aVDB
000177455 980__ $$aI:(DE-He78)E041-20160331
000177455 980__ $$aUNRESTRICTED