TY  - THES
AU  - Baltazar, Filipa
TI  - FLASH optimization for multi-beam proton therapy
PB  - IST, University of Lisbon
VL  - Masterarbeit
M1  - DKFZ-2021-02547
PY  - 2021
N1  - Corresponding author: J. Seco
N1  - Masterarbeit, IST, University of Lisbon, 2021
AB  - Radiotherapy is a balancing act between maximizing tumor control and minimizing radiation-inducedtoxicity. FLASH radiotherapy has shown promising results in reducing the healthy tissue damage for thesame level of tumor toxicity. This work aims at the development of a treatment plan strategy for FLASHradiotherapy, considering multiple proton beams. In order to allow that, we must divide the target indifferent regions. Each region is irradiated with either FLASH or conventional beams, and then webring the different irradiated regions all together in an optimized stitching geometry. Different tools andmethods of incorporating dose rate into treatment planning were explored. Particularly, both sequentialand simultaneous dose and dose rate optimization techniques were studied, and specific treatment planswere implemented. Results showed the potential of the stitching geometry in accommodating multipleFLASH beams in homogeneous target irradiation, while preventing the creation of overdosing scenarios.For a treatment plan considering one FLASH and three conventional beams whose dose and dose ratewere sequentially optimized, a homogeneity index of 0.14 and a D2
LB  - PUB:(DE-HGF)19
UR  - https://inrepo02.dkfz.de/record/177455
ER  -