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000177457 0247_ $$2ISSN$$a1931-5244
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000177457 037__ $$aDKFZ-2021-02549
000177457 041__ $$aEnglish
000177457 082__ $$a610
000177457 1001_ $$aRodriguez, Mariana Ponce de Leon$$b0
000177457 245__ $$aNovel associations between inflammation-related proteins and adiposity: a targeted proteomics approach across four population-based studies.
000177457 260__ $$aNew York, NY$$bElsevier$$c2022
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000177457 500__ $$aVolume 242, April 2022, Pages 93-104
000177457 520__ $$aChronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last two decades, the complex interplay between immune regulators and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development.
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000177457 7001_ $$aLinseisen, Jakob$$b1
000177457 7001_ $$aPeters, Annette$$b2
000177457 7001_ $$aLinkohr, Birgit$$b3
000177457 7001_ $$aHeier, Margit$$b4
000177457 7001_ $$aGrallert, Harald$$b5
000177457 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b6$$udkfz
000177457 7001_ $$0P:(DE-He78)b09508a4c4afe85c57dd131eefa689ea$$aTrares, Kira$$b7$$udkfz
000177457 7001_ $$0P:(DE-He78)ac7aed57f26354e8a484b5d257f7bada$$aBhardwaj, Megha$$b8$$udkfz
000177457 7001_ $$0P:(DE-He78)8218df9f6f41792399cd3a29b587e4e7$$aGào, Xīn$$b9$$udkfz
000177457 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Herman$$b10$$udkfz
000177457 7001_ $$aKamiński, Karol Adam$$b11
000177457 7001_ $$aPaniczko, Marlena$$b12
000177457 7001_ $$aKowalska, Irina$$b13
000177457 7001_ $$aBaumeister, Sebastian-Edgar$$b14
000177457 7001_ $$aMeisinger, Christa$$b15
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