TY  - JOUR
AU  - Rodriguez, Mariana Ponce de Leon
AU  - Linseisen, Jakob
AU  - Peters, Annette
AU  - Linkohr, Birgit
AU  - Heier, Margit
AU  - Grallert, Harald
AU  - Schöttker, Ben
AU  - Trares, Kira
AU  - Bhardwaj, Megha
AU  - Gào, Xīn
AU  - Brenner, Herman
AU  - Kamiński, Karol Adam
AU  - Paniczko, Marlena
AU  - Kowalska, Irina
AU  - Baumeister, Sebastian-Edgar
AU  - Meisinger, Christa
TI  - Novel associations between inflammation-related proteins and adiposity: a targeted proteomics approach across four population-based studies.
JO  - Translational research
VL  - 242
SN  - 1931-5244
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2021-02549
SP  - 93-104
PY  - 2022
N1  - Volume 242, April 2022, Pages 93-104
AB  - Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last two decades, the complex interplay between immune regulators and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development.
LB  - PUB:(DE-HGF)16
C6  - pmid:34780968
DO  - DOI:10.1016/j.trsl.2021.11.004
UR  - https://inrepo02.dkfz.de/record/177457
ER  -