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@ARTICLE{Khoja:177465,
      author       = {L. Khoja and R. P. Weber and P. M. Webb and S. J. Jordan
                      and A. Muthukumar and J. Chang-Claude$^*$ and R. T.
                      Fortner$^*$ and A. Jensen and S. K. Kjaer and H. Risch and
                      J. A. Doherty and H. R. Harris and M. T. Goodman and F.
                      Modugno and K. Moysich and A. Berchuck and J. M. Schildkraut
                      and D. Cramer and K. L. Terry and H. Anton-Culver and A.
                      Ziogas and M. T. Phung and G. E. Hanley and A. H. Wu and B.
                      Mukherjee and K. McLean and K. Cho and M. C. Pike and C. L.
                      Pearce and A. W. Lee},
      collaboration = {A. O. C. S. Group},
      title        = {{E}ndometriosis and menopausal hormone therapy impact the
                      hysterectomy-ovarian cancer association.},
      journal      = {Gynecologic oncology},
      volume       = {164},
      number       = {1},
      issn         = {0090-8258},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-02557},
      pages        = {195-201},
      year         = {2022},
      note         = {2022 Jan;164(1):195-201},
      abstract     = {To evaluate the association between hysterectomy and
                      ovarian cancer, and to understand how hormone therapy (HT)
                      use and endometriosis affect this association.We conducted a
                      pooled analysis of self-reported data from 11 case-control
                      studies in the Ovarian Cancer Association Consortium (OCAC).
                      Women with (n = 5350) and without ovarian cancer
                      (n = 7544) who never used HT or exclusively used either
                      estrogen-only therapy (ET) or estrogen+progestin therapy
                      (EPT) were included. Risk of invasive epithelial ovarian
                      cancer adjusted for duration of ET and EPT use and
                      stratified on history of endometriosis was determined using
                      odds ratios (ORs) with $95\%$ confidence intervals
                      (CIs).Overall and among women without endometriosis, there
                      was a positive association between ovarian cancer risk and
                      hysterectomy (OR = 1.19, $95\%$ CI 1.09-1.31 and
                      OR = 1.20, $95\%$ CI 1.09-1.32, respectively), but no
                      association upon adjusting for duration of ET and EPT use
                      (OR = 1.04, $95\%$ CI 0.94-1.16 and OR = 1.06, $95\%$ CI
                      0.95-1.18, respectively). Among women with a history of
                      endometriosis, there was a slight inverse association
                      between hysterectomy and ovarian cancer risk (OR = 0.93,
                      $95\%$ CI 0.69-1.26), but this association became stronger
                      and statistically significant after adjusting for duration
                      of ET and EPT use (OR = 0.69, $95\%$ CI 0.48-0.99).The
                      hysterectomy-ovarian cancer association is complex and
                      cannot be understood without considering duration of ET and
                      EPT use and history of endometriosis. Failure to take these
                      exposures into account in prior studies casts doubt on their
                      conclusions. Overall, hysterectomy is not risk-reducing for
                      ovarian cancer, however the inverse association among women
                      with endometriosis warrants further investigation.},
      keywords     = {Endometriosis (Other) / Hormone therapy (Other) /
                      Hysterectomy (Other) / Ovarian cancer (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34776242},
      doi          = {10.1016/j.ygyno.2021.10.088},
      url          = {https://inrepo02.dkfz.de/record/177465},
}