%0 Journal Article
%A Rubanova, Yulia
%A Shi, Ruian
%A Harrigan, Caitlin F
%A Li, Roujia
%A Wintersinger, Jeff
%A Sahin, Nil
%A Deshwar, Amit
%A PCAWGEvolution
%A Group, Heterogeneity Working
%A Morris, Quaid
%A PCAWGConsortium
%T Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
%J Nature Communications
%V 11
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2021-02570
%P 731
%D 2020
%Z siehe Correction: DKFZ Autoren affiliiert im PCAWG Consortium: https://inrepo02.dkfz.de/record/212434   /    https://doi.org/10.1038/s41467-022-32336-7
%X The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliable methods to reconstruct evolutionary trajectories of mutational signature activity. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data from 2658 cancers across 38 tumour types, we present TrackSig, a new method that reconstructs these trajectories using optimal, joint segmentation and deconvolution of mutation type and allele frequencies from a single tumour sample. In simulations, we find TrackSig has a 3-5
%K Computational Biology: methods
%K Computer Simulation
%K Evolution, Molecular
%K Gene Frequency
%K Genome, Human
%K Humans
%K Mutation
%K Neoplasms: genetics
%K Neoplasms: pathology
%K Polymorphism, Single Nucleotide
%K Whole Genome Sequencing
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32024834
%2 pmc:PMC7002414
%R 10.1038/s41467-020-14352-7
%U https://inrepo02.dkfz.de/record/177483