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@ARTICLE{Hemminki:177490,
      author       = {K. Hemminki$^*$ and A. Försti$^*$ and T. Chen and A.
                      Hemminki},
      title        = {{I}ncidence, mortality and survival in malignant pleural
                      mesothelioma before and after asbestos in {D}enmark,
                      {F}inland, {N}orway and {S}weden.},
      journal      = {BMC cancer},
      volume       = {21},
      number       = {1},
      issn         = {1471-2407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-02577},
      pages        = {1189},
      year         = {2021},
      note         = {#EA:C050#},
      abstract     = {Malignant pleural mesothelioma (MPM) is a rare but fatal
                      cancer, which is largely caused by exposure to asbestos.
                      Reliable information about the incidence of MPM prior the
                      influence of asbestos is lacking. The nationwide regional
                      incidence trends for MPM remain poorly characterized. We use
                      nationwide MPM data for Denmark (DK), Finland (FI), Norway
                      (NO) and Sweden (SE) to assess incidence, mortality and
                      survival trends for MPM in these countries.We use the
                      NORDCAN database for the analyses: incidence data were
                      available from 1943 in DK, 1953 in FI and NO and 1958 in SE,
                      through 2016. Survival data were available from 1967 through
                      2016. World standard population was used in age
                      standardization.The lowest incidence that we recorded for
                      MPM was 0.02/100,000 for NO women and 0.05/100,000 for FI
                      men in 1953-57, marking the incidence before the influence
                      of asbestos. The highest rate of 1.9/100,000 was recorded
                      for DK in 1997. Female incidence was much lower than male
                      incidence. In each country, the male incidence trend for MPM
                      culminated, first in SE around 1990. The regional incidence
                      trends matched with earlier asbestos-related industrial
                      activity, shipbuilding in FI and SE, cement manufacturing
                      and shipbuilding in DK and seafaring in NO. Relative 1-year
                      survival increased from about 20 to $50\%$ but 5-year
                      survival remained at or below $10\%.In$ the Nordic
                      countries, the male incidence trends for MPM climaxed and
                      started to decrease, indicating that the prevention of
                      exposure was beneficial. Survival in MPM has improved for
                      both sexes but long-term survival remains dismal.},
      keywords     = {Age-specific incidence (Other) / Birth cohort analysis
                      (Other) / Incidence trends (Other) / Regional incidence
                      (Other) / Relative survival (Other) / Risk factors (Other)},
      cin          = {C050 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34749677},
      pmc          = {pmc:PMC8576876},
      doi          = {10.1186/s12885-021-08913-2},
      url          = {https://inrepo02.dkfz.de/record/177490},
}