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000177496 1001_ $$aCharvat, Hadrien$$b0
000177496 245__ $$aExcess body fatness during early to mid-adulthood and survival from colorectal and breast cancer: a pooled analysis of five international cohort studies.
000177496 260__ $$aPhiladelphia, Pa.$$bAACR$$c2022
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000177496 500__ $$a2022 Feb;31(2):325-333
000177496 520__ $$aHere, we explore the association between excess weight during early to mid-adulthood and survival in patients diagnosed with breast and colorectal cancer, using a pooled analysis of five cohort studies and study participants from 11 countries.Participant-level BMI trajectories were estimated by fitting a growth curve model using over 2 million repeated BMI measurements from close to 600,000 cohort participants. Cumulative measures of excess weight were derived. Data from over 23,000 breast and colorectal cancer patients were subsequently analyzed using time-to-event models for death with the date of diagnosis as start of follow-up. Study-specific results were combined through a random effect meta-analysis.We found a significant dose-response relationship (p-trend=0.013) between the average BMI during early and mid-adulthood and death from breast cancer, with a pooled hazard ratio of 1.31 (1.07, 1.60) and the time to death shortened by 16% for average BMI above 25 kg/m2 compared with average BMI less or equal to 22.5 kg/m2, respectively. Similar results were found for categories of cumulative time spent with excess weight. There was no association between excess body fatness during early to mid-adulthood and death in colorectal cancer patients.Excess body fatness during early to mid-adulthood is not only associated with an increased risk of developing cancer, but also with a lower survival in breast cancer patients.Our results emphasize the importance of public health policies aimed at reducing overweight during adulthood and inform future studies on the relationship between excess weight and cancer outcomes.
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000177496 7001_ $$00000-0001-8648-4998$$aFreisling, Heinz$$b1
000177496 7001_ $$00000-0002-6978-8364$$aNoh, Hwayoung$$b2
000177496 7001_ $$00000-0002-6429-4007$$aGaudet, Mia M$$b3
000177496 7001_ $$00000-0001-5472-6761$$aGunter, Marc J$$b4
000177496 7001_ $$00000-0002-0893-2377$$aCross, Amanda J$$b5
000177496 7001_ $$aTsilidis, Konstantinos K$$b6
000177496 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b7
000177496 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b8$$udkfz
000177496 7001_ $$00000-0001-5064-227X$$aBergmann, Manuela$$b9
000177496 7001_ $$00000-0003-4472-1179$$aAgnoli, Claudia$$b10
000177496 7001_ $$aRylander, Charlotta$$b11
000177496 7001_ $$00000-0003-2476-4251$$aSkeie, Guri$$b12
000177496 7001_ $$aJakszyn, Paula$$b13
000177496 7001_ $$00000-0003-0066-0677$$aRosendahl, Ann H$$b14
000177496 7001_ $$00000-0002-7516-9543$$aSund, Malin$$b15
000177496 7001_ $$00000-0001-7157-419X$$aSeveri, Gianluca$$b16
000177496 7001_ $$aTsugane, Shoichiro$$b17
000177496 7001_ $$00000-0002-9936-1476$$aSawada, Norie$$b18
000177496 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b19$$udkfz
000177496 7001_ $$aAdami, Hans-Olov$$b20
000177496 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b21
000177496 7001_ $$aSoerjomataram, Isabelle$$b22
000177496 7001_ $$aArnold, Melina$$b23
000177496 773__ $$0PERI:(DE-600)2036781-8$$a10.1158/1055-9965.EPI-21-0688$$gp. cebp.0688.2021 -$$n2$$p325-333$$tCancer epidemiology, biomarkers & prevention$$v31$$x1538-7755$$y2022
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