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@ARTICLE{Charvat:177496,
      author       = {H. Charvat and H. Freisling and H. Noh and M. M. Gaudet and
                      M. J. Gunter and A. J. Cross and K. K. Tsilidis and A.
                      Tjønneland and V. Katzke$^*$ and M. Bergmann and C. Agnoli
                      and C. Rylander and G. Skeie and P. Jakszyn and A. H.
                      Rosendahl and M. Sund and G. Severi and S. Tsugane and N.
                      Sawada and H. Brenner$^*$ and H.-O. Adami and E. Weiderpass
                      and I. Soerjomataram and M. Arnold},
      title        = {{E}xcess body fatness during early to mid-adulthood and
                      survival from colorectal and breast cancer: a pooled
                      analysis of five international cohort studies.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {31},
      number       = {2},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2021-02583},
      pages        = {325-333},
      year         = {2022},
      note         = {2022 Feb;31(2):325-333},
      abstract     = {Here, we explore the association between excess weight
                      during early to mid-adulthood and survival in patients
                      diagnosed with breast and colorectal cancer, using a pooled
                      analysis of five cohort studies and study participants from
                      11 countries.Participant-level BMI trajectories were
                      estimated by fitting a growth curve model using over 2
                      million repeated BMI measurements from close to 600,000
                      cohort participants. Cumulative measures of excess weight
                      were derived. Data from over 23,000 breast and colorectal
                      cancer patients were subsequently analyzed using
                      time-to-event models for death with the date of diagnosis as
                      start of follow-up. Study-specific results were combined
                      through a random effect meta-analysis.We found a significant
                      dose-response relationship (p-trend=0.013) between the
                      average BMI during early and mid-adulthood and death from
                      breast cancer, with a pooled hazard ratio of 1.31 (1.07,
                      1.60) and the time to death shortened by $16\%$ for average
                      BMI above 25 kg/m2 compared with average BMI less or equal
                      to 22.5 kg/m2, respectively. Similar results were found for
                      categories of cumulative time spent with excess weight.
                      There was no association between excess body fatness during
                      early to mid-adulthood and death in colorectal cancer
                      patients.Excess body fatness during early to mid-adulthood
                      is not only associated with an increased risk of developing
                      cancer, but also with a lower survival in breast cancer
                      patients.Our results emphasize the importance of public
                      health policies aimed at reducing overweight during
                      adulthood and inform future studies on the relationship
                      between excess weight and cancer outcomes.},
      cin          = {C020 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34782393},
      doi          = {10.1158/1055-9965.EPI-21-0688},
      url          = {https://inrepo02.dkfz.de/record/177496},
}