guest ::
| Home > Publications database > Excess body fatness during early to mid-adulthood and survival from colorectal and breast cancer: a pooled analysis of five international cohort studies. > print |
| Home > Publications database > Excess body fatness during early to mid-adulthood and survival from colorectal and breast cancer: a pooled analysis of five international cohort studies. > print |
| 001 | 177496 | ||
| 005 | 20240229133742.0 | ||
| 024 | 7 | _ | |a 10.1158/1055-9965.EPI-21-0688 |2 doi |
| 024 | 7 | _ | |a pmid:34782393 |2 pmid |
| 024 | 7 | _ | |a 1055-9965 |2 ISSN |
| 024 | 7 | _ | |a 1538-7755 |2 ISSN |
| 024 | 7 | _ | |a altmetric:117032169 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-02583 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Charvat, Hadrien |b 0 |
| 245 | _ | _ | |a Excess body fatness during early to mid-adulthood and survival from colorectal and breast cancer: a pooled analysis of five international cohort studies. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2022 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1644585194_13689 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2022 Feb;31(2):325-333 |
| 520 | _ | _ | |a Here, we explore the association between excess weight during early to mid-adulthood and survival in patients diagnosed with breast and colorectal cancer, using a pooled analysis of five cohort studies and study participants from 11 countries.Participant-level BMI trajectories were estimated by fitting a growth curve model using over 2 million repeated BMI measurements from close to 600,000 cohort participants. Cumulative measures of excess weight were derived. Data from over 23,000 breast and colorectal cancer patients were subsequently analyzed using time-to-event models for death with the date of diagnosis as start of follow-up. Study-specific results were combined through a random effect meta-analysis.We found a significant dose-response relationship (p-trend=0.013) between the average BMI during early and mid-adulthood and death from breast cancer, with a pooled hazard ratio of 1.31 (1.07, 1.60) and the time to death shortened by 16% for average BMI above 25 kg/m2 compared with average BMI less or equal to 22.5 kg/m2, respectively. Similar results were found for categories of cumulative time spent with excess weight. There was no association between excess body fatness during early to mid-adulthood and death in colorectal cancer patients.Excess body fatness during early to mid-adulthood is not only associated with an increased risk of developing cancer, but also with a lower survival in breast cancer patients.Our results emphasize the importance of public health policies aimed at reducing overweight during adulthood and inform future studies on the relationship between excess weight and cancer outcomes. |
| 536 | _ | _ | |a 313 - Krebsrisikofaktoren und Prävention (POF4-313) |0 G:(DE-HGF)POF4-313 |c POF4-313 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 700 | 1 | _ | |a Freisling, Heinz |0 0000-0001-8648-4998 |b 1 |
| 700 | 1 | _ | |a Noh, Hwayoung |0 0000-0002-6978-8364 |b 2 |
| 700 | 1 | _ | |a Gaudet, Mia M |0 0000-0002-6429-4007 |b 3 |
| 700 | 1 | _ | |a Gunter, Marc J |0 0000-0001-5472-6761 |b 4 |
| 700 | 1 | _ | |a Cross, Amanda J |0 0000-0002-0893-2377 |b 5 |
| 700 | 1 | _ | |a Tsilidis, Konstantinos K |b 6 |
| 700 | 1 | _ | |a Tjønneland, Anne |0 0000-0003-4385-2097 |b 7 |
| 700 | 1 | _ | |a Katzke, Verena |0 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 |b 8 |u dkfz |
| 700 | 1 | _ | |a Bergmann, Manuela |0 0000-0001-5064-227X |b 9 |
| 700 | 1 | _ | |a Agnoli, Claudia |0 0000-0003-4472-1179 |b 10 |
| 700 | 1 | _ | |a Rylander, Charlotta |b 11 |
| 700 | 1 | _ | |a Skeie, Guri |0 0000-0003-2476-4251 |b 12 |
| 700 | 1 | _ | |a Jakszyn, Paula |b 13 |
| 700 | 1 | _ | |a Rosendahl, Ann H |0 0000-0003-0066-0677 |b 14 |
| 700 | 1 | _ | |a Sund, Malin |0 0000-0002-7516-9543 |b 15 |
| 700 | 1 | _ | |a Severi, Gianluca |0 0000-0001-7157-419X |b 16 |
| 700 | 1 | _ | |a Tsugane, Shoichiro |b 17 |
| 700 | 1 | _ | |a Sawada, Norie |0 0000-0002-9936-1476 |b 18 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 19 |u dkfz |
| 700 | 1 | _ | |a Adami, Hans-Olov |b 20 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |0 0000-0003-2237-0128 |b 21 |
| 700 | 1 | _ | |a Soerjomataram, Isabelle |b 22 |
| 700 | 1 | _ | |a Arnold, Melina |b 23 |
| 773 | _ | _ | |a 10.1158/1055-9965.EPI-21-0688 |g p. cebp.0688.2021 - |0 PERI:(DE-600)2036781-8 |n 2 |p 325-333 |t Cancer epidemiology, biomarkers & prevention |v 31 |y 2022 |x 1538-7755 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:177496 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 19 |6 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-313 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Krebsrisikofaktoren und Prävention |x 0 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-02-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-02-02 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-02-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-10 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-10 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-10 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-10 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2022-11-10 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-10 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b CANCER EPIDEM BIOMAR : 2021 |d 2022-11-10 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-10 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2022-11-10 |
| 920 | 1 | _ | |0 I:(DE-He78)C020-20160331 |k C020 |l C020 Epidemiologie von Krebs |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)C070-20160331 |k C070 |l C070 Klinische Epidemiologie und Alternf. |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)C020-20160331 |
| 980 | _ | _ | |a I:(DE-He78)C070-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|