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000177539 041__ $$aEnglish
000177539 082__ $$a610
000177539 1001_ $$00000-0002-9028-0290$$aSteur, Marinka$$b0
000177539 245__ $$aDietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries.
000177539 260__ $$aNew York, NY$$bAssociation$$c2021
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000177539 500__ $$a2021 Dec 7;10(23):e019814
000177539 520__ $$aBackground There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. Methods and Results We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88-0.99]), cheese (HR, 0.98 [95% CI, 0.96-1.00]), and fish (HR, 0.87 [95% CI, 0.75-1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02-1.12]) and butter (HR, 1.02 [95% CI, 1.00-1.04]). Conclusions This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.
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000177539 650_7 $$2Other$$acoronary heart disease
000177539 650_7 $$2Other$$adietary guidelines
000177539 650_7 $$2Other$$anutritional epidemiology
000177539 650_7 $$2Other$$aprimary prevention
000177539 650_7 $$2Other$$asaturated fat
000177539 7001_ $$aJohnson, Laura$$b1
000177539 7001_ $$aSharp, Stephen J$$b2
000177539 7001_ $$00000-0002-6841-8396$$aImamura, Fumiaki$$b3
000177539 7001_ $$aSluijs, Ivonne$$b4
000177539 7001_ $$00000-0003-2294-307X$$aKey, Timothy J$$b5
000177539 7001_ $$aWood, Angela$$b6
000177539 7001_ $$00000-0003-4881-5690$$aChowdhury, Rajiv$$b7
000177539 7001_ $$00000-0001-9242-6364$$aGuevara, Marcela$$b8
000177539 7001_ $$00000-0001-6518-4136$$aJakobsen, Marianne U$$b9
000177539 7001_ $$00000-0002-9227-8434$$aJohansson, Ingegerd$$b10
000177539 7001_ $$aKoulman, Albert$$b11
000177539 7001_ $$aOvervad, Kim$$b12
000177539 7001_ $$aSánchez, Maria-José$$b13
000177539 7001_ $$avan der Schouw, Yvonne T$$b14
000177539 7001_ $$aTrichopoulou, Antonia$$b15
000177539 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b16
000177539 7001_ $$aWennberg, Maria$$b17
000177539 7001_ $$aZheng, Ju-Sheng$$b18
000177539 7001_ $$aBoeing, Heiner$$b19
000177539 7001_ $$00000-0002-9714-4304$$aBoer, Jolanda M A$$b20
000177539 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b21
000177539 7001_ $$aEricson, Ulrika$$b22
000177539 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b23
000177539 7001_ $$00000-0003-3838-855X$$aHuybrechts, Inge$$b24
000177539 7001_ $$00000-0002-3777-4953$$aImaz, Liher$$b25
000177539 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b26$$udkfz
000177539 7001_ $$aKrogh, Vittorio$$b27
000177539 7001_ $$aKühn, Tilman$$b28
000177539 7001_ $$aKyrø, Cecilie$$b29
000177539 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b30
000177539 7001_ $$aMelander, Olle$$b31
000177539 7001_ $$aMoreno-Iribas, Conchi$$b32
000177539 7001_ $$aPanico, Salvatore$$b33
000177539 7001_ $$aQuirós, José R$$b34
000177539 7001_ $$aRodríguez-Barranco, Miguel$$b35
000177539 7001_ $$aSacerdote, Carlotta$$b36
000177539 7001_ $$aSantiuste, Carmen$$b37
000177539 7001_ $$aSkeie, Guri$$b38
000177539 7001_ $$aTjønneland, Anne$$b39
000177539 7001_ $$aTumino, Rosario$$b40
000177539 7001_ $$aVerschuren, W M Monique$$b41
000177539 7001_ $$00000-0002-6236-6804$$aZamora-Ros, Raul$$b42
000177539 7001_ $$aDahm, Christina C$$b43
000177539 7001_ $$00000-0002-5652-356X$$aPerez-Cornago, Aurora$$b44
000177539 7001_ $$aSchulze, Matthias B$$b45
000177539 7001_ $$00000-0002-0284-8959$$aTong, Tammy Y N$$b46
000177539 7001_ $$aRiboli, Elio$$b47
000177539 7001_ $$00000-0003-1422-2993$$aWareham, Nicholas J$$b48
000177539 7001_ $$aDanesh, John$$b49
000177539 7001_ $$aButterworth, Adam S$$b50
000177539 7001_ $$00000-0002-5041-248X$$aForouhi, Nita G$$b51
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