TY  - JOUR
AU  - Li, Xiangwei
AU  - Zhang, Yan
AU  - Gào, Xīn
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Brenner, Hermann
TI  - Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study.
JO  - EBioMedicine
VL  - 74
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2021-02628
SP  - 103686
PY  - 2021
N1  - #EA:C070#LA:C070#LA:C120
AB  - Three DNA methylation (DNAm) based algorithms, DNAm PhenoAge acceleration (AgeAccelPheno), DNAm GrimAge acceleration (AgeAccelGrim), and mortality risk score (MRscore), based on methylation in 513, 1030, and 10 CpGs, respectively, were established to predict health outcomes and mortality. We aimed to compare and validate the predictive ability of these scores and frailty in relation to mortality in a population-based cohort from Germany.DNA methylation in whole blood was measured by the Infinium Methylation EPIC BeadChip kit (EPIC, Illumina, San Diego, CA, USA) in two random subsets of the ESTHER cohort study (n = 741 and n = 1030). AgeAccelPheno, AgeAccelGrim, and a revised MRscore to adapt EPIC, the MRscore with 8 CpGs (MRscore-8CpGs), were calculated. Frailty was assessed by a frailty index (FI).During 17 years of follow-up, 458 deaths were observed. All DNAm algorithms and FI were positively correlated with each other. AgeAccelPheno, AgeAccelGrim, MRscore, and FI showed independent associations with all-cause mortality [hazard ratio (95
KW  - DNA methylation (Other)
KW  - age acceleration (Other)
KW  - epigenetic clock (Other)
KW  - frailty (Other)
KW  - mortality (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34808433
DO  - DOI:10.1016/j.ebiom.2021.103686
UR  - https://inrepo02.dkfz.de/record/177561
ER  -