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000177565 1001_ $$00000-0003-1721-4083$$aMori, Nagisa$$b0
000177565 245__ $$aEndogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis.
000177565 260__ $$aOxford$$bOxford University Press$$c2021
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000177565 520__ $$aObservational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results.We investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone-binding globulin (SHBG) with colon cancer risk in a nested case-control study of 1028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were noncurrent users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios and 95% confidence intervals to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided.In the multivariable model, a nonstatistically significantly positive relationship was found between circulating estrone and colon cancer risk (odds ratio per log2 1-unit increment = 1.17 [95% confidence interval = 1.00 to 1.38]; odds ratioquartile4-quartile1 = 1.33 [95% confidence interval = 0.89 to 1.97], P trend = .20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol and estrone concentrations with colorectal, colon, and rectal cancer risk.Our observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal women.
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000177565 7001_ $$00000-0001-9437-3040$$aKeski-Rahkonen, Pekka$$b1
000177565 7001_ $$aGicquiau, Audrey$$b2
000177565 7001_ $$00000-0002-6846-1204$$aRinaldi, Sabina$$b3
000177565 7001_ $$aDimou, Niki$$b4
000177565 7001_ $$00000-0001-8540-6891$$aHarlid, Sophia$$b5
000177565 7001_ $$00000-0002-4759-2643$$aHarbs, Justin$$b6
000177565 7001_ $$aVan Guelpen, Bethany$$b7
000177565 7001_ $$00000-0002-4533-1722$$aAune, Dagfinn$$b8
000177565 7001_ $$00000-0002-0893-2377$$aCross, Amanda J$$b9
000177565 7001_ $$00000-0002-8452-8472$$aTsilidis, Konstantinos K$$b10
000177565 7001_ $$00000-0001-7157-419X$$aSeveri, Gianluca$$b11
000177565 7001_ $$00000-0002-4557-3772$$aKvaskoff, Marina$$b12
000177565 7001_ $$00000-0001-8380-3439$$aFournier, Agnès$$b13
000177565 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b14$$udkfz
000177565 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aTurzanski-Fortner, Renée$$b15$$udkfz
000177565 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b16
000177565 7001_ $$aJakszyn, Paula$$b17
000177565 7001_ $$aSánchez, Maria-Jose$$b18
000177565 7001_ $$aColorado-Yohar, Sandra M$$b19
000177565 7001_ $$00000-0001-8434-2013$$aArdanaz, Eva$$b20
000177565 7001_ $$aTravis, Ruth$$b21
000177565 7001_ $$00000-0001-9229-2589$$aWatts, Eleanor L$$b22
000177565 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b23
000177565 7001_ $$00000-0003-0122-8624$$aKrogh, Vittorio$$b24
000177565 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b25
000177565 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b26
000177565 7001_ $$aPanico, Salvatore$$b27
000177565 7001_ $$aBueno-de-Mesquita, Bas$$b28
000177565 7001_ $$00000-0002-0031-4152$$aGram, Inger Torhild$$b29
000177565 7001_ $$aWaaseth, Marit$$b30
000177565 7001_ $$aGunter, Marc J$$b31
000177565 7001_ $$aMurphy, Neil$$b32
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