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@ARTICLE{Mori:177565,
      author       = {N. Mori and P. Keski-Rahkonen and A. Gicquiau and S.
                      Rinaldi and N. Dimou and S. Harlid and J. Harbs and B. Van
                      Guelpen and D. Aune and A. J. Cross and K. K. Tsilidis and
                      G. Severi and M. Kvaskoff and A. Fournier and R. Kaaks$^*$
                      and R. Turzanski-Fortner$^*$ and M. B. Schulze and P.
                      Jakszyn and M.-J. Sánchez and S. M. Colorado-Yohar and E.
                      Ardanaz and R. Travis and E. L. Watts and G. Masala and V.
                      Krogh and R. Tumino and C. Sacerdote and S. Panico and B.
                      Bueno-de-Mesquita and I. T. Gram and M. Waaseth and M. J.
                      Gunter and N. Murphy},
      title        = {{E}ndogenous {C}irculating {S}ex {H}ormone {C}oncentrations
                      and {C}olon {C}ancer {R}isk in {P}ostmenopausal {W}omen: {A}
                      {P}rospective {S}tudy and {M}eta-{A}nalysis.},
      journal      = {JNCI cancer spectrum},
      volume       = {5},
      number       = {6},
      issn         = {2515-5091},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-02632},
      pages        = {pkab084},
      year         = {2021},
      abstract     = {Observational studies have consistently reported that
                      postmenopausal hormone therapy use is associated with lower
                      colon cancer risk, but epidemiologic studies examining the
                      associations between circulating concentrations of
                      endogenous estrogens and colorectal cancer have reported
                      inconsistent results.We investigated the associations
                      between circulating concentrations of estrone, estradiol,
                      free estradiol, testosterone, free testosterone,
                      androstenedione, dehydroepiandrosterone (DHEA),
                      progesterone, and sex hormone-binding globulin (SHBG) with
                      colon cancer risk in a nested case-control study of 1028
                      postmenopausal European women (512 colon cancer cases, 516
                      matched controls) who were noncurrent users of exogenous
                      hormones at blood collection. Multivariable conditional
                      logistic regression models were used to compute odds ratios
                      and $95\%$ confidence intervals to evaluate the association
                      between circulating sex hormones and colon cancer risk. We
                      also conducted a dose-response meta-analysis of prospective
                      studies of circulating estrone and estradiol with
                      colorectal, colon, and rectal cancer risk in postmenopausal
                      women. All statistical tests were 2-sided.In the
                      multivariable model, a nonstatistically significantly
                      positive relationship was found between circulating estrone
                      and colon cancer risk (odds ratio per log2 1-unit increment
                      = 1.17 $[95\%$ confidence interval = 1.00 to 1.38]; odds
                      ratioquartile4-quartile1 = 1.33 $[95\%$ confidence interval
                      = 0.89 to 1.97], P trend = .20). Circulating concentrations
                      of estradiol, free estradiol, testosterone, free
                      testosterone, androstenedione, DHEA, progesterone, and SHBG
                      were not associated with colon cancer risk. In the
                      dose-response meta-analysis, no clear evidence of
                      associations were found between circulating estradiol and
                      estrone concentrations with colorectal, colon, and rectal
                      cancer risk.Our observational and meta-analysis results do
                      not support an association between circulating
                      concentrations of endogenous sex hormones and colon or
                      rectal cancer in postmenopausal women.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34805742},
      pmc          = {pmc:PMC8598284},
      doi          = {10.1093/jncics/pkab084},
      url          = {https://inrepo02.dkfz.de/record/177565},
}