%0 Journal Article
%A Bobdiwala, Shabnam
%A Kyriacou, Christopher
%A Christodoulou, Evangelia
%A Farren, Jessica
%A Mitchell-Jones, Nicola
%A Al-Memar, Maya
%A Ayim, Francis
%A Chohan, Baljinder
%A Kirk, Emma
%A Abughazza, Osama
%A Guruwadahyarhalli, Bramara
%A Guha, Sharmistha
%A Vathanan, Veluppillai
%A Gould, Debbie
%A Stalder, Catriona
%A Timmerman, Dirk
%A Van Calster, Ben
%A Bourne, Tom
%T Evaluating cut-off levels for progesterone, β human chorionic gonadotropin and β human chorionic gonadotropin ratio to exclude pregnancy viability in women with a pregnancy of unknown location: A prospective multicenter cohort study.
%J Acta obstetricia et gynecologica Scandinavica
%V 101
%N 1
%@ 0001-6349
%C Malden, MA
%I Wiley-Blackwell
%M DKFZ-2021-02662
%P 46-55
%D 2022
%Z 2022 Jan;101(1):46-55
%X There is no global agreement on how to best determine pregnancy of unknown location viability and location using biomarkers. Measurements of progesterone and β human chorionic gonadotropin (βhCG) are still used in clinical practice to exclude the possibility of a viable intrauterine pregnancy (VIUP). We evaluate the predictive value of progesterone, βhCG, and βhCG ratio cut-off levels to exclude a VIUP in women with a pregnancy of unknown location.This was a secondary analysis of prospective multicenter study data of consecutive women with a pregnancy of unknown location between January 2015 and 2017 collected from dedicated early pregnancy assessment units of eight hospitals. Single progesterone and serial βhCG measurements were taken. Women were followed up until final pregnancy outcome between 11 and 14 weeks of gestation was confirmed using transvaginal ultrasonography: (1) VIUP, (2) non-viable intrauterine pregnancy or failed pregnancy of unknown location, and (3) ectopic pregnancy or persisting pregnancy of unknown location. The predictive value of cut-off levels for ruling out VIUP were evaluated across a range of values likely to be encountered clinically for progesterone, βhCG, and βhCG ratio.Data from 2507 of 3272 (76.6
%K early pregnancy complications (Other)
%K ectopic pregnancy (Other)
%K pregnancy (Other)
%K pregnancy of unknown location (Other)
%K reproductive endocrinology (Other)
%K ultrasound (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34817062
%R 10.1111/aogs.14295
%U https://inrepo02.dkfz.de/record/177603