%0 Journal Article
%A Stepien, Magdalena
%A Lopez-Nogueroles, Marina
%A Lahoz, Agustin
%A Kühn, Tilman
%A Perlemuter, Gabriel
%A Voican, Cosmin
%A Ciocan, Dragos
%A Boutron-Ruault, Marie-Christine
%A Jansen, Eugene
%A Viallon, Vivian
%A Leitzmann, Michael
%A Tjønneland, Anne
%A Severi, Gianluca
%A Mancini, Francesca Romana
%A Dong, Catherine
%A Kaaks, Rudolf
%A Fortner, Renee Turzanski
%A Bergmann, Manuela M
%A Boeing, Heiner
%A Trichopoulou, Antonia
%A Karakatsani, Anna
%A Peppa, Eleni
%A Palli, Domenico
%A Krogh, Vittorio
%A Tumino, Rosario
%A Sacerdote, Carlotta
%A Panico, Salvatore
%A Bueno-de-Mesquita, H Bas
%A Skeie, Guri
%A Merino, Susana
%A Ros, Raul Zamora
%A Sánchez, Maria Jose
%A Amiano, Pilar
%A Huerta, Jose Mª
%A Barricarte, Aurelio
%A Sjöberg, Klas
%A Ohlsson, Bodil
%A Nyström, Hanna
%A Werner, Marten
%A Perez-Cornago, Aurora
%A Schmidt, Julie A
%A Freisling, Heinz
%A Scalbert, Augustin
%A Weiderpass, Elisabete
%A Christakoudi, Sofia
%A Gunter, Marc J
%A Jenab, Mazda
%T Pre-diagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma.
%J International journal of cancer
%V 150
%N 8
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2021-02752
%P 1255-1268
%D 2022
%Z Volume150, Issue8, 15 April 2022, Pages 1255-1268
%X Bile acids (BA) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory, and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/un-conjugated) in pre-diagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling  = 2.30, 95
%K bile acid metabolism (Other)
%K biomarkers (Other)
%K cancer prevention (Other)
%K hepatocellular carcinoma (Other)
%K obesity (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34843121
%R 10.1002/ijc.33885
%U https://inrepo02.dkfz.de/record/177704