TY  - JOUR
AU  - Stepien, Magdalena
AU  - Lopez-Nogueroles, Marina
AU  - Lahoz, Agustin
AU  - Kühn, Tilman
AU  - Perlemuter, Gabriel
AU  - Voican, Cosmin
AU  - Ciocan, Dragos
AU  - Boutron-Ruault, Marie-Christine
AU  - Jansen, Eugene
AU  - Viallon, Vivian
AU  - Leitzmann, Michael
AU  - Tjønneland, Anne
AU  - Severi, Gianluca
AU  - Mancini, Francesca Romana
AU  - Dong, Catherine
AU  - Kaaks, Rudolf
AU  - Fortner, Renee Turzanski
AU  - Bergmann, Manuela M
AU  - Boeing, Heiner
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - Peppa, Eleni
AU  - Palli, Domenico
AU  - Krogh, Vittorio
AU  - Tumino, Rosario
AU  - Sacerdote, Carlotta
AU  - Panico, Salvatore
AU  - Bueno-de-Mesquita, H Bas
AU  - Skeie, Guri
AU  - Merino, Susana
AU  - Ros, Raul Zamora
AU  - Sánchez, Maria Jose
AU  - Amiano, Pilar
AU  - Huerta, Jose Mª
AU  - Barricarte, Aurelio
AU  - Sjöberg, Klas
AU  - Ohlsson, Bodil
AU  - Nyström, Hanna
AU  - Werner, Marten
AU  - Perez-Cornago, Aurora
AU  - Schmidt, Julie A
AU  - Freisling, Heinz
AU  - Scalbert, Augustin
AU  - Weiderpass, Elisabete
AU  - Christakoudi, Sofia
AU  - Gunter, Marc J
AU  - Jenab, Mazda
TI  - Pre-diagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma.
JO  - International journal of cancer
VL  - 150
IS  - 8
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2021-02752
SP  - 1255-1268
PY  - 2022
N1  - Volume150, Issue8, 15 April 2022, Pages 1255-1268
AB  - Bile acids (BA) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory, and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/un-conjugated) in pre-diagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling  = 2.30, 95
KW  - bile acid metabolism (Other)
KW  - biomarkers (Other)
KW  - cancer prevention (Other)
KW  - hepatocellular carcinoma (Other)
KW  - obesity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34843121
DO  - DOI:10.1002/ijc.33885
UR  - https://inrepo02.dkfz.de/record/177704
ER  -