%0 Journal Article
%A Elter, Alina
%A Rippke, Carolin
%A Johnen, Wibke
%A Mann, Philipp
%A Hellwich, Emily
%A Schwahofer, Andrea
%A Dorsch, Stefan
%A Buchele, Carolin
%A Klüter, Sebastian
%A Karger, Christian
%T End-to-end test for fractionated online adaptive MR-guided radiotherapy using a deformable anthropomorphic pelvis phantom.
%J Physics in medicine and biology
%V 66
%@ 0031-9155
%C Bristol
%I IOP Publ.
%M DKFZ-2021-02761
%P 245021
%D 2021
%Z #EA:E040#LA:E040# /  66 245021
%X In MR-guided radiotherapy (MRgRT) for prostate cancer treatments inter-fractional anatomy changes such as bladder and rectum fillings may be corrected by an online adaption of the treatment plan. To clinically implement such complex treatment procedures, however, specific end-to-end tests are required that are able to validate the overall accuracy of all treatment steps from pre-treatment imaging to dose delivery.In this study, an end-to-end test of a fractionated and online adapted MRgRT prostate irradiation was performed using the so-called ADAM-PETer phantom. The phantom was adapted to perform 3D polymer gel (PG) dosimetry in the prostate and rectum. Furthermore, thermoluminescence detectors (TLDs) were placed at the center and on the surface of the prostate for additional dose measurements as well as for an external dose renormalization of the PG. For the end-to-end test, a total of five online adapted irradiations were applied in sequence with different bladder and rectum fillings, respectively.A good agreement of measured and planned dose was found represented by high γ-index passing rates (3 
%K 3D gel dosimetry (PAGAT) (Other)
%K Magnetic resonance-guided (adaptive) radiotherapy (MRgRT) (Other)
%K deformable anthropomorphic pelvis phantom (Other)
%K end-to-end test (Other)
%K fractionated treatment (Other)
%K inter-fractional motion (Other)
%K thermoluminescence detectors (TLD) (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34845991
%R 10.1088/1361-6560/ac3e0c
%U https://inrepo02.dkfz.de/record/177720