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000177720 1001_ $$0P:(DE-He78)d6ff1f04f2e927518e4290cc7dec3133$$aElter, Alina$$b0$$eFirst author$$udkfz
000177720 245__ $$aEnd-to-end test for fractionated online adaptive MR-guided radiotherapy using a deformable anthropomorphic pelvis phantom.
000177720 260__ $$aBristol$$bIOP Publ.$$c2021
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000177720 520__ $$aIn MR-guided radiotherapy (MRgRT) for prostate cancer treatments inter-fractional anatomy changes such as bladder and rectum fillings may be corrected by an online adaption of the treatment plan. To clinically implement such complex treatment procedures, however, specific end-to-end tests are required that are able to validate the overall accuracy of all treatment steps from pre-treatment imaging to dose delivery.In this study, an end-to-end test of a fractionated and online adapted MRgRT prostate irradiation was performed using the so-called ADAM-PETer phantom. The phantom was adapted to perform 3D polymer gel (PG) dosimetry in the prostate and rectum. Furthermore, thermoluminescence detectors (TLDs) were placed at the center and on the surface of the prostate for additional dose measurements as well as for an external dose renormalization of the PG. For the end-to-end test, a total of five online adapted irradiations were applied in sequence with different bladder and rectum fillings, respectively.A good agreement of measured and planned dose was found represented by high γ-index passing rates (3 %⁄ 3 mm criterion) of the PG evaluation of 98.9 % in the prostate and 93.7 % in the rectum. TLDs used for PG renormalization at the center of the prostate showed a deviation of -2.3 %.The presented end-to-end test, which allows for 3D dose verification in the prostate and rectum, demonstrates the feasibility and accuracy of fractionated and online-adapted prostate irradiations in presence of inter-fractional anatomy changes. Such tests are of high clinical importance for the commissioning of new image-guided treatment procedures such as online adaptive MRgRT.
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000177720 650_7 $$2Other$$a3D gel dosimetry (PAGAT)
000177720 650_7 $$2Other$$aMagnetic resonance-guided (adaptive) radiotherapy (MRgRT)
000177720 650_7 $$2Other$$adeformable anthropomorphic pelvis phantom
000177720 650_7 $$2Other$$aend-to-end test
000177720 650_7 $$2Other$$afractionated treatment
000177720 650_7 $$2Other$$ainter-fractional motion
000177720 650_7 $$2Other$$athermoluminescence detectors (TLD)
000177720 7001_ $$aRippke, Carolin$$b1
000177720 7001_ $$0P:(DE-He78)5c55eb63ee2ad2499f7dda0ed08c571b$$aJohnen, Wibke$$b2$$udkfz
000177720 7001_ $$0P:(DE-He78)d26409e0d07007daf771142a945102ef$$aMann, Philipp$$b3$$udkfz
000177720 7001_ $$0P:(DE-He78)fb88b16550eaa8f0583422c5add94ef1$$aHellwich, Emily$$b4$$udkfz
000177720 7001_ $$0P:(DE-He78)8918404541688dee7976f7546be900fe$$aSchwahofer, Andrea$$b5$$udkfz
000177720 7001_ $$0P:(DE-He78)e43f53a20835bd25906f1795558151a3$$aDorsch, Stefan$$b6$$udkfz
000177720 7001_ $$aBuchele, Carolin$$b7
000177720 7001_ $$aKlüter, Sebastian$$b8
000177720 7001_ $$0P:(DE-He78)b43076fb0a30230e4323887c0c980046$$aKarger, Christian$$b9$$eLast author$$udkfz
000177720 773__ $$0PERI:(DE-600)1473501-5$$a10.1088/1361-6560/ac3e0c$$p245021$$tPhysics in medicine and biology$$v66$$x0031-9155$$y2021
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