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000177734 1001_ $$0P:(DE-HGF)0$$aWillscher, Edith$$b0
000177734 245__ $$aHigh-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas.
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000177734 520__ $$aMolecular mechanisms of lower-grade (II-III) diffuse gliomas (LGG) are still poorly understood, mainly because of their heterogeneity. They split into astrocytoma- (IDH-A) and oligodendroglioma-like (IDH-O) tumors both carrying mutations(s) at the isocitrate dehydrogenase (IDH) gene and into IDH wild type (IDH-wt) gliomas of glioblastoma resemblance. We generated detailed maps of the transcriptomes and DNA methylomes, revealing that cell functions divided into three major archetypic hallmarks: (i) increased proliferation in IDH-wt and, to a lesser degree, IDH-O; (ii) increased inflammation in IDH-A and IDH-wt; and (iii) the loss of synaptic transmission in all subtypes. Immunogenic properties of IDH-A are diverse, partly resembling signatures observed in grade IV mesenchymal glioblastomas or in grade I pilocytic astrocytomas. We analyzed details of coregulation between gene expression and DNA methylation and of the immunogenic micro-environment presumably driving tumor development and treatment resistance. Our transcriptome and methylome maps support personalized, case-by-case views to decipher the heterogeneity of glioma states in terms of data portraits. Thereby, molecular cartography provides a graphical coordinate system that links gene-level information with glioma subtypes, their phenotypes, and clinical context.
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000177734 650_7 $$2Other$$aDNA methylation
000177734 650_7 $$2Other$$agene expression
000177734 650_7 $$2Other$$agrade II–IV gliomas
000177734 650_7 $$2Other$$aintegrative bioinformatics
000177734 650_7 $$2Other$$amolecular subtypes
000177734 650_7 $$2Other$$aself-organizing maps machine learning
000177734 650_7 $$2Other$$atumor evolution
000177734 650_7 $$2Other$$atumor heterogeneity
000177734 7001_ $$aHopp, Lydia$$b1
000177734 7001_ $$aKreuz, Markus$$b2
000177734 7001_ $$00000-0002-5317-3920$$aSchmidt, Maria$$b3
000177734 7001_ $$aHakobyan, Siras$$b4
000177734 7001_ $$00000-0002-6851-1056$$aArakelyan, Arsen$$b5
000177734 7001_ $$aHentschel, Bettina$$b6
000177734 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David T W$$b7
000177734 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b8
000177734 7001_ $$aLoeffler, Markus$$b9
000177734 7001_ $$0P:(DE-HGF)0$$aLoeffler-Wirth, Henry$$b10
000177734 7001_ $$00000-0002-2242-4678$$aBinder, Hans$$b11
000177734 773__ $$0PERI:(DE-600)2527080-1$$a10.3390/cancers13133198$$gVol. 13, no. 13, p. 3198 -$$n13$$p3198$$tCancers$$v13$$x2072-6694$$y2021
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